Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Introduction to the Potential of Ferula Ovina in Dental Implant Research Due to Estrogenic Bioactive Compounds and Adhesive Properties Publisher Pubmed



Mirakabad HZ1 ; Khorramizadeh MR2, 3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Anatomy, Physiology and Pharmacology, University of Saskatchewan, Saskatoon, Canada
  2. 2. Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  3. 3. Zebrafish Core Facility, Endocrinology and Metabolism Research Institute (EMRI), TUMS, Tehran, Iran

Source: PLoS ONE Published:2022


Abstract

Recent developments in dental implant have heightened the urgent need to natural tissue adhesives estrogenic materials with ability of promoting the proliferation and osteoblastic differentiation in human dental pulp-derived stem cells, to provide better integration of tissue for dentistry. Up to now, far little attention has been paid to adhesives extract of the root of Ferula sp. which contains biomaterial compounds with estrogenic activities. Prior to undertaking the investigation, analysis of the extract of the root of F. ovina revealed a novel terpenoid, and we identified it as Fenoferin. So far, this paper has focused on Fenoferin compared to Ferutinin and root extract to determine if Fenoferin caused changes in craniofacial cartilage, bone (ceratohyal) and tooth mineralization. Following the purpose of study, we used zebrafish as a well-developed model system for studying bone development, so the developing zebrafish larvae were exposed to various concentration of compounds at 2dpf, and the histological analyses were performed at 6dpf. The result of the current study highlights the importance of F. ovina in studies related to dental regenerative medicine. © 2022 Zare Mirakabad, Khorramizadeh. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.