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Prevalence of Helicobacter Pylori Among Sudanese Patients Diagnosed With Colon Polyps and Colon Cancer Using Immunohistochemistry Technique Publisher Pubmed



Mohamed AK1 ; Elhassan NM1 ; Awhag ZA1 ; Ali FS1 ; Ali ET1, 2 ; Mhmoud NA3, 4 ; Siddig EE3, 5, 6 ; Hassan R3 ; Ahmed ES3 ; Fattahi A7 ; Ahmed A8 ; Muneer MS9, 10, 11 ; Osman HA12 ; Mohamed NS13, 14, 15 Show All Authors
Authors
  1. Mohamed AK1
  2. Elhassan NM1
  3. Awhag ZA1
  4. Ali FS1
  5. Ali ET1, 2
  6. Mhmoud NA3, 4
  7. Siddig EE3, 5, 6
  8. Hassan R3
  9. Ahmed ES3
  10. Fattahi A7
  11. Ahmed A8
  12. Muneer MS9, 10, 11
  13. Osman HA12
  14. Mohamed NS13, 14, 15
  15. Edris AMM1, 16
Show Affiliations
Authors Affiliations
  1. 1. Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan
  2. 2. Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, National University, Sudan, Khartoum, Sudan
  3. 3. Mycetoma Research Center, University of Khartoum, Khartoum, Sudan
  4. 4. Department of Microbiology and Immunology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan
  5. 5. School of Medicine, Nile University, Khartoum, Sudan
  6. 6. Department of Histopathology and Cytology, Alfarrabi College for Science and Technology, Khartoum, Sudan
  7. 7. Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Parasitology and Medical Entomology, Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
  9. 9. Department of Neurology, Mayo Clinic, Jacksonville, FL, United States
  10. 10. Department of Radiology, Mayo Clinic, Jacksonville, FL, United States
  11. 11. Department of Internal Medicine, Faculty of Medicine, University of Khartoum, Khartoum, Sudan
  12. 12. Biomedical Research Laboratory, Ahfad University for Women, Omdurman, Sudan
  13. 13. Molecular Biology Department, Alfarrabi College for Sciences and Technology, Khartoum, Sudan
  14. 14. Department of Parasitology and Medical Entomology, Faculty of Medicine, Sinnar University, Sinnar, Sudan
  15. 15. Department of Parasitology and Medical Entomology, Faculty of Medical Laboratory Sciences, Nile University, Khartoum, Sudan
  16. 16. Faculty of Applied Medical Sciences, University of Bisha, Bisha, Saudi Arabia

Source: BMC Research Notes Published:2020


Abstract

Objectives: Infection with the bacteria Helicobacter pylori has been classified as class one carcinogen associated with increasing susceptibility of gastritis and gastric carcinoma. This study is aiming at investigating the prevalence of H. pylori among colon polyps and colon cancer patients. A descriptive cross-sectional hospital-based study was conducted between February and June 2017. Sixty-nine formalin-fixed paraffin blocks collected from colon polyps and colon cancer patients to detect H. pylori using immunohistochemistry technique. Results: Of the 69 patients included in the study, 39 (56.5%) males and 30 (43.5%) were females, their age ranged from 21 to 80 years with a mean age of 47.1 ± 19.7. Of the 69 colon polyps and colon cancer patients, 44 (63.8%) were diagnosed as adenocarcinoma, 10 (14.5%) colitis, 15 (21.7%) juvenile polyposis syndrome. The results of immunohistochemistry technique showed the presence of 16 (23.2%) positive patients for H. pylori infection. Of these 16, 13 (81.3%) patients were diagnosed with adenocarcinoma and 3 (18.7%) patients were diagnosed with juvenile polyps. The results of H. pylori detection among the different colon polyps and colon cancer patients were showing a statistically significant association for H. pylori infection and adenocarcinoma, P value 0.028. © 2020 The Author(s).
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