Cardiac Chronotropic Hypo-Responsiveness and Atrial Fibrosis in Rats Chronically Treated With Lithium

Cardiac Chronotropic Hypo-Responsiveness and Atrial Fibrosis in Rats Chronically Treated With Lithium Publisher Pubmed

Moradi S¹ ; Aminian A² ; Abdollahi A³ ; Jazayeri A⁴ ; Ghamami G¹ ; Nikoui V¹ ; Bakhtiarian A¹ ; Jazaeri F¹

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1. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Pharmacology, School of Medicine, Arak University of Medical Sciences, Arak, Iran
3. Department of Pathology, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Pharmacology, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran

Source: Autonomic Neuroscience: Basic and Clinical Published:2019

Abstract

Lithium is a widely used mood-stabilizing agent; however, it causes a variety of cardiovascular side effects including sinus node dysfunction. In this study we explored the potential adverse effects of lithium on cardiac chronotropic responsiveness, atrial tissue histology and gene expression in rats that were chronically treated with therapeutic doses of lithium. Male Wistar albino rats were given lithium chloride (2.5 g/kg) orally for 2 or 3 months. Following treatment, the atria were isolated and spontaneously beating rate and chronotropic responsiveness to β-adrenergic stimulation was evaluated in an organ bath. Development of cardiac fibrosis was examined by histological methods. The expression of atrial Col1a1 (collagen I, alpha 1) and β-arrestin2 was also assessed using quantitative RT-PCR. Treatment with lithium induced a significant hypo-responsiveness to adrenergic stimulation (P < 0.001) and caused fibrosis in the atrial tissue of treated rats. In addition, the expression of atrial Col1a1 mRNA was significantly increased in atrial tissues of lithium-treated animals, while β-arrestin2 mRNA expression did not show a significant difference compared with control animals. Altogether, these findings indicate that cardiac chronotropic hypo responsiveness and associated cardiac fibrosis are side effects of chronic lithium treatment. Moreover, it seems that lithium treatment does not influence β-arrestin2 mRNA expression. © 2018 Elsevier B.V.

Style	Citing Format
MLA	Moradi S, et al.. "Cardiac Chronotropic Hypo-Responsiveness and Atrial Fibrosis in Rats Chronically Treated With Lithium." Autonomic Neuroscience: Basic and Clinical, vol. 216, no. , 2019, pp. 46-50.
APA	Moradi S, Aminian A, Abdollahi A, Jazayeri A, Ghamami G, Nikoui V, Bakhtiarian A, Jazaeri F (2019). Cardiac Chronotropic Hypo-Responsiveness and Atrial Fibrosis in Rats Chronically Treated With Lithium. Autonomic Neuroscience: Basic and Clinical, 216(), 46-50.
Chicago	Moradi S, Aminian A, Abdollahi A, Jazayeri A, Ghamami G, Nikoui V, Bakhtiarian A, Jazaeri F. "Cardiac Chronotropic Hypo-Responsiveness and Atrial Fibrosis in Rats Chronically Treated With Lithium." Autonomic Neuroscience: Basic and Clinical 216, no. (2019): 46-50.
Harvard	Moradi S et al. (2019) 'Cardiac Chronotropic Hypo-Responsiveness and Atrial Fibrosis in Rats Chronically Treated With Lithium', Autonomic Neuroscience: Basic and Clinical, 216(), pp. 46-50.
Vancouver	Moradi S, Aminian A, Abdollahi A, Jazayeri A, Ghamami G, Nikoui V, et al.. Cardiac Chronotropic Hypo-Responsiveness and Atrial Fibrosis in Rats Chronically Treated With Lithium. Autonomic Neuroscience: Basic and Clinical. 2019;216():46-50.
BibTex	@article{ author = {Moradi S and Aminian A and Abdollahi A and Jazayeri A and Ghamami G and Nikoui V and Bakhtiarian A and Jazaeri F}, title = {Cardiac Chronotropic Hypo-Responsiveness and Atrial Fibrosis in Rats Chronically Treated With Lithium}, journal = {Autonomic Neuroscience: Basic and Clinical}, volume = {216}, number = {}, pages = {46-50}, year = {2019} }
RIS	TY - JOUR AU - Moradi S AU - Aminian A AU - Abdollahi A AU - Jazayeri A AU - Ghamami G AU - Nikoui V AU - Bakhtiarian A AU - Jazaeri F TI - Cardiac Chronotropic Hypo-Responsiveness and Atrial Fibrosis in Rats Chronically Treated With Lithium JO - Autonomic Neuroscience: Basic and Clinical VL - 216 IS - SP - 46 EP - 50 PY - 2019 ER -

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