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Effects of Coating Layer and Release Medium on Release Profile From Coated Capsules With Eudragit Fs 30D: An in Vitro and in Vivo Study Publisher Pubmed



Moghimipour E1, 2 ; Rezaei M3 ; Kouchak M1 ; Fatahiasl J4 ; Angali KA5 ; Ramezani Z1 ; Amini M6 ; Dorkoosh FA7, 8 ; Handali S1
Authors
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Authors Affiliations
  1. 1. Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  2. 2. Cellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  3. 3. Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  4. 4. Department of Radiographic Technology, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  5. 5. Department of Biostatistics, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. 6. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Medical Biomaterial Research Centre (MBRC), Tehran University of Medical Sciences, Tehran, Iran

Source: Drug Development and Industrial Pharmacy Published:2018


Abstract

The aim of the present research was to evaluate the impact of coating layers on release profile from enteric coated dosage forms. Capsules were coated with Eudragit FS 30D using dipping method. The drug profile was evaluated in both phosphate buffer and Hank’s solutions. Utilization X-ray imaging, gastrointestinal transmission of enteric coated capsules was traced in rats. According to the results, no release of the drug was found at pH 1.2, and the extent of release drug in pH 6.8 medium was decreased by adding the coating layers. The results indicated single-layer coated capsules in phosphate buffer were significantly higher than that in Hank’s solution. However, no significant difference was observed from capsules with three coating layers in two different dissolution media. X-ray imaging showed that enteric coated capsules were intact in the stomach and in the small intestine, while disintegrated in the colon. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
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Somayeh Handali (2)
Farid Dorkoosh (2)