Reconstructing Sentence Processing in Aphasia: A Randomised Control Trial of a Usage-Based Intervention Publisher



C Bruns CLAUDIA ; F Rodgers FERN ; K Dathan KERRY ; Mp Dean Michael P ; Je Warren Jane E ; V Fleming VICTORIA ; Aha Javadi Amirhomayoun Homayoun A ; Ra Varley Rosemary A
Source: Aphasiology Published:2025

Abstract

Background: Listening to and producing sentences is a cornerstone of typical language exchanges. Therapy for aphasic impairments has tended to focus on single-word processing, with comparatively few sentence-level therapies. Usage-based Construction Grammar is an approach to language in which frequency of use of grammatical constructions plays a central role in representation and processing of structures. We report findings from a usage-based sentence intervention: UTILISE (Unification Therapy Integrating LexIcon and SEntences). The intervention began by priming high-frequency constructions (e.g. I like it) via listening tasks and then practice of production. Subsequently, different lexical items were inserted to slots around the verb (e.g. I like coffee now) to increase communicative options. Aims: To evaluate the impact of UTILISE on participants’ spoken sentence production and comprehension abilities. Methods & procedures: Participants with chronic aphasia (n = 39) were recruited to a two-arm randomised control trial, with 33 participants completing the intervention. At trial entry, participants were randomised to Immediate/Deferred conditions, allowing for treatment/no treatment comparison. Two baseline measures were taken (four-week interval in the Immediate condition; eight-week interval in Deferred). A four-week therapy phase comprised two auditory processing tasks and one spoken sentence production task, delivered over 12 in-person sessions. Outcomes were measured immediately post-intervention and after an eight-week maintenance phase. Main outcome measures were: sentence production in narratives, measured as ratio of three-word combinations to total words in connected speech (Connectivity); spoken sentence comprehension (TROG-2) and quality of life (QoL) perceptions (SAQOL-39). Intervention acceptability was also evaluated, together with an untreated control task. Outcomes & results: A between-group comparison of Connectivity and TROG-2 scores revealed no significant difference; however, when data were pooled across groups, linear mixed-effects models revealed gains following therapy in Connectivity, whereas increases in sentence comprehension (TROG-2) scores might be due to repeated exposure to the test. QoL perceptions improved, reaching significance on the SAQOL-39 communication sub-scale. Participants found the UTILISE intervention acceptable. Conclusions: The study produced initial indications of the value of a usage-based sentence therapy, with increases in three-word combinations in connected speech, enhanced QoL ratings regarding communication, and high acceptability to participants. A number of factors may affect results: intervention was delivered at low-dose, and both production and comprehension measures represented distal measures. However, given these preliminary results, UTILISE has now been developed into an app enabling higher-dose intervention, and is currently under evaluation. Trial registration: Prospectively registered on 13/09/2019 at ISRCTN14466044. © 2025 Elsevier B.V., All rights reserved.