Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Nmr Spectroscopy-Based Metabolomic Study of Serum in Sulfur Mustard Exposed Patients With Lung Disease Publisher Pubmed



Arefi Oskouie A2 ; Rezaeitavirani M1 ; Aliannejad R3 ; Taheri S4 ; Fathi F5 ; Taghi Naseri M6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Basic Sciences, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Pulmonary Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Chemistry and Chemical Engineering Research Center of Iran, Tehran, Iran
  5. 5. Department of Chemistry, Sharif University of Technology, Tehran, Iran
  6. 6. Department of Chemistry, Faculty of Sciences, Tarbiat Modares University, Tehran, Iran

Source: Biomarkers Published:2017


Abstract

Sulfur mustard (SM) is a vesication chemical warfare agent for which there is currently no antidote. Despite years of research, there is no common consensus about the pathophysiological basis of chronic pulmonary disease caused by this chemical warfare agent. In this study, we combined chemometric techniques with nuclear magnetic resonance (NMR) spectroscopy to explore the metabolic profile of sera from SM-exposed patients. A total of 29 serum samples obtained from 17 SM-injured patients, and 12 healthy controls were analyzed by Random Forest. Increased concentrations of seven amino acids, glycerol, dimethylamine, ketone bodies, lactate, acetate, citrulline and creatine together with the decreased very low-density lipoproteins (VLDL) levels were observed in patients compared with control subjects. Our study reveals the metabolic profile of sera from SM-injured patients and indicates that NMR-based methods can distinguish these patients from healthy controls. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
View other Related Docs
1. Nmr- and Gc/Ms-Based Metabolomics of Sulfur Mustard Exposed Individuals: A Pilot Study, Biomarkers (2016)
2. Metabolomics Diagnostic Approach to Mustard Airway Diseases: A Preliminary Study, Iranian Journal of Basic Medical Sciences (2018)
3. Nuclear Magnetic Resonance -Based Metabolomics Analysis of Patients Exposed to Sulfur Mustard in Different Stages Using Random Forest Method, Koomesh (2016)
4. Pro-Oxidant–Antioxidant Balance in Iranian Veterans With Sulfur Mustard Toxicity and Different Levels of Pulmonary Disorders, Drug and Chemical Toxicology (2016)
5. Metabolomics Analysis of the Saliva in Patients With Chronic Hepatitis B Using Nuclear Magnetic Resonance: A Pilot Study, Iranian Journal of Basic Medical Sciences (2019)
6. The Footprint of Tgf-Β in Airway Remodeling of the Mustard Lung, Inhalation Toxicology (2015)
7. Characterization of Lung Fibroblasts More Than Two Decades After Mustard Gas Exposure, PLoS ONE (2015)
8. Long Term Follow-Up of Sulfur Mustard Related Bronchiolitis Obliterans Treatment, Acta Medica Iranica (2016)
Experts (# of related papers)
View all Related Experts
Rasoul Aliannejad (5)
Payman Salamati (1)
Other Related Docs
9. The Predictive Association Between Radiological Findings and Lung Cancer Development in Patients Exposed to Sulfur Mustard Gas: 4 Decades Follow up of 719 Victims, BMC Pulmonary Medicine (2022)
10. Th17/Treg Immunoregulation and Implications in Treatment of Sulfur Mustard Gas-Induced Lung Diseases, Expert Review of Clinical Immunology (2017)
11. Circulating Mesenchymal Stem Cells in Sulfur Mustard-Exposed Patients With Long-Term Pulmonary Complications, Toxicology Letters (2019)
12. Study of Colorectal Polyps Using 1H Nuclear Magnetic Resonance Spectroscopy, Koomesh (2016)
13. The Metabolome Profiling of Obese and Non-Obese Individuals: Metabolically Healthy Obese and Unhealthy Non-Obese Paradox, Iranian Journal of Basic Medical Sciences (2020)
14. Paraclinical Findings in Iranian Veterans Exposed to Sulfur Mustard Gas: A Literature Review, Chinese Journal of Traumatology - English Edition (2017)
15. Staging of Colorectal Cancer Using Serum Metabolomics With1hnmr Spectroscopy, Iranian Journal of Basic Medical Sciences (2017)
16. The Levels of Exhaled Nitric Oxide in Mustard Airway Disease, Trauma Monthly (2022)