Aspirin Desensitization for Patients With Aspirin-Exacerbated Respiratory Disease: A Randomized Double-Blind Placebo-Controlled Trial

Aspirin Desensitization for Patients With Aspirin-Exacerbated Respiratory Disease: A Randomized Double-Blind Placebo-Controlled Trial Publisher Pubmed

Esmaeilzadeh H^{1, 2} ; Nabavi M¹ ; Aryan Z³ ; Arshi S¹ ; Bemanian MH¹ ; Fallahpour M¹ ; Mortazavi N⁴

Show Affiliations

1. Department of Allergy and Immunology, Rasool-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
2. Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3. Students' Scientific Research Center, Tehran University of Medical Sciences, Iran
4. Department of Clinical Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Clinical Immunology Published:2015

Abstract

The effect of aspirin desensitization (AD) on immunologic profile of patients with AERD has been poorly understood. This study is aimed at investigating the effect of AD on clinical and immunological markers of patients with AERD. This randomized double-blind placebo-controlled trial comprised 34 adult patients (67.6% female) with chronic rhinosinusitis, nasal polyps, and aspirin-intolerant asthma. The active group underwent AD over a 2-day period with increasing doses of aspirin (60, 125, 325, and 625. mg), followed by receiving aspirin 625. mg twice daily for 6. months. Symptom scores and medication needs of patients with AERD who have undergone AD were significantly lower compared to the placebo group after 6. months (7.5 ± 3.5 vs. 10.6 ± 3.8 and 9.3 ± 2.0 vs. 11.0 ± 3.1, respectively, all p. <. 0.05). However, no significant difference was observed in serum concentration of IL-10, IFN-γ, and TGF-β between two groups neither at baseline nor at the end of study. © 2015 Elsevier Inc.

2. Hla-Drb and Hla-Dq Genetic Variability in Patients With Aspirin-Exacerbated Respiratory Disease, American Journal of Rhinology and Allergy (2015)

3. The Effect of Aspirin on Moderate to Severe Asthmatic Patients With Aspirin Hypersensitivity, Chronic Rhinosinusitis, and Nasal Polyposis, Iranian Journal of Allergy# Asthma and Immunology (2021)

4. Innate Lymphoid Cells Are Pivotal Actors in Allergic, Inflammatory and Autoimmune Diseases, Expert Review of Clinical Immunology (2015)

5. Investigation of the Relationship Between Aspirin-Sensitivity and Poor Response to Medical Management in Nsaids-Exacerbated Respiratory Disease Patients With Sinonasal Polyposis, Medical Journal of the Islamic Republic of Iran (2023)

Experts (# of related papers)

Nima Rezaei (2)

Ali Akbar Amirzargar (2)

Style	Citing Format
MLA	Esmaeilzadeh H, et al.. "Aspirin Desensitization for Patients With Aspirin-Exacerbated Respiratory Disease: A Randomized Double-Blind Placebo-Controlled Trial." Clinical Immunology, vol. 160, no. 2, 2015, pp. 349-357.
APA	Esmaeilzadeh H, Nabavi M, Aryan Z, Arshi S, Bemanian MH, Fallahpour M, Mortazavi N (2015). Aspirin Desensitization for Patients With Aspirin-Exacerbated Respiratory Disease: A Randomized Double-Blind Placebo-Controlled Trial. Clinical Immunology, 160(2), 349-357.
Chicago	Esmaeilzadeh H, Nabavi M, Aryan Z, Arshi S, Bemanian MH, Fallahpour M, Mortazavi N. "Aspirin Desensitization for Patients With Aspirin-Exacerbated Respiratory Disease: A Randomized Double-Blind Placebo-Controlled Trial." Clinical Immunology 160, no. 2 (2015): 349-357.
Harvard	Esmaeilzadeh H et al. (2015) 'Aspirin Desensitization for Patients With Aspirin-Exacerbated Respiratory Disease: A Randomized Double-Blind Placebo-Controlled Trial', Clinical Immunology, 160(2), pp. 349-357.
Vancouver	Esmaeilzadeh H, Nabavi M, Aryan Z, Arshi S, Bemanian MH, Fallahpour M, et al.. Aspirin Desensitization for Patients With Aspirin-Exacerbated Respiratory Disease: A Randomized Double-Blind Placebo-Controlled Trial. Clinical Immunology. 2015;160(2):349-357.
BibTex	@article{ author = {Esmaeilzadeh H and Nabavi M and Aryan Z and Arshi S and Bemanian MH and Fallahpour M and Mortazavi N}, title = {Aspirin Desensitization for Patients With Aspirin-Exacerbated Respiratory Disease: A Randomized Double-Blind Placebo-Controlled Trial}, journal = {Clinical Immunology}, volume = {160}, number = {2}, pages = {349-357}, year = {2015} }
RIS	TY - JOUR AU - Esmaeilzadeh H AU - Nabavi M AU - Aryan Z AU - Arshi S AU - Bemanian MH AU - Fallahpour M AU - Mortazavi N TI - Aspirin Desensitization for Patients With Aspirin-Exacerbated Respiratory Disease: A Randomized Double-Blind Placebo-Controlled Trial JO - Clinical Immunology VL - 160 IS - 2 SP - 349 EP - 357 PY - 2015 ER -

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