The Impact of Liraglutide on Urogenital and Reproductive System in Mice Publisher



M Ebrahimi MEHDI ; A Namazi Shabestari ALIREZA ; N Ahmadi NAVID ; R Mashhadi RAHIL ; Sf Hosseini Seyedeh FATEMEH ; P Zahmatkesh PARISA ; L Zareian Baghdadabad LEILA ; A Khajavi ALIREZA ; G Mesbah GHOLAMREZA ; J Raouf Sarshoori JAVAD
Source: Translational Research in Urology Published:2024

Abstract

Introduction We aimed to evaluate whether Liraglutide can remove the deteriorating impact of a high-fat diet (HF) diet on the genitourinary system. Methods Fifty-six C57 mice were recruited of which received an HF as the intervention group, and a chow diet (CH) as a control group. After two months the case group was sub-grouped into three groups; 1: group HF with a daily injection of 0.4mg/kg liraglutide (HF+Lir), 2: CH with a daily injection of 0.4mg/kg liraglutide (CH+Lir), and 3: HF diet with an infusion of normal saline (HF+NS). After two months, all mice were sacrificed for additional testing. Results Serological analysis showed no significant difference for lipid profile (P-value>0.05) and hormones except for PSA in males (P-value=0.019). This significance was seen when comparing CH+Lir and HF+NS to the control group (P-values=0.014 and 0.025, respectively). Liraglutide decreases testosterone in both genders and adiponectin and insulin in males. Total sperm count was decreased, and the difference between the groups was significant (P-value=0.013). Conclusions Liraglutide cannot recover the deteriorating impact of an HF diet on sperm morphology and motility but can improve the sperm DFI and the total number of sperm. © 2024 Elsevier B.V., All rights reserved.