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The Impact of Functional Promoter Variants in Interleukin‑18 on Susceptibility to Rheumatoid Arthritis in Iranian Population Publisher



Ramezanzadeh M1 ; Khodabandehloo F2 ; Alesaeidi S3 ; Mousavi SH4 ; Sadeghi S5 ; Ehtesham N6 ; Mosallaei M2, 7 ; Hazrati E8
Authors
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Authors Affiliations
  1. 1. Department of Genetics and Molecular Medicine, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
  2. 2. Department of Genetics and Advanced Medical Technology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran
  3. 3. Department of Internal Medicine and Rheumatology, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Cardiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran
  5. 5. Surgical Department, Imam Reza Hospital, Facualy of Medicine, AJA University of Medical Sciences, Tehran, Iran
  6. 6. Department of Medical Genetics, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran
  7. 7. Personalized Medicine and Genometabolomics Research Center, Hope Generation Foundation, Tehran, Iran
  8. 8. Department Anesthesiology and Critical Care, AJA University of Medical Sciences, Tehran, Iran

Source: Advanced Biomedical Research Published:2024


Abstract

Background: Interleukin‑18 (IL‑18) is recognized for its pro‑inflammatory properties and plays a central role in the progression of rheumatoid arthritis (RA). The specific single‑nucleotide polymorphisms (SNPs), rs1946518 (‑607C>A) and rs187238 (‑137G>C), that are found in the IL‑18 promoter region can potentially impact the expression of the IL‑18 gene. This study aimed to investigate the correlation between these two polymorphisms and RA in the Iranian population. Materials and Methods: In this study, we conducted a case–control analysis with a total of 275 subjects consisting of 135 patients with RA and 140 controls. The high‑resolution melting (HRM) method, performed through real‑time polymerase chain reaction, was utilized for genotyping these polymorphisms. Results: Regarding the rs1946518 polymorphism, the frequency of AA and CA genotypes and allele A was significantly greater in the control group compared to the RA group (AA vs CC; OR: 0.42; 95%CI [0.198‑0.872], CA vs CC; OR: 0.57; 95%CI [0.324‑1.001], A vs C; OR: 0.58; 95%CI [0.401‑0.836] (P < 0.05). There was no statistically significant difference in the frequency of genotypes and allele frequencies between the control and patient groups in terms of the rs187238 polymorphism (P > 0.05). The level of both the C‑reactive protein (CRP) and erythrocyte sedimentation rate (ESR) was notably elevated in the patient group with CC genotype in rs1946518 (P < 0.05). Conclusion: In the rs1946518 polymorphism, the AA and AC genotypes and the A allele demonstrated protective effects in RA. Besides, the CC genotype was associated with some laboratory characteristics in the RA group. © 2024 Advanced Biomedical Research.
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