Alteration in Serum Levels of Tumor Necrosis Factor Alpha Is Associated With Histopathologic Progression of Gastric Cancer

Alteration in Serum Levels of Tumor Necrosis Factor Alpha Is Associated With Histopathologic Progression of Gastric Cancer Publisher Pubmed

Alikhani M¹ ; Esmaeili M¹ ; Tashakoripour M² ; Mohagheghi MA³ ; Hosseini ME² ; Touati E⁴ ; Vosough M⁵ ; Mohammadi M¹

Show Affiliations

1. HPGC Research Group, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
2. Gastroenterology Department, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran
3. Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
4. Institut Pasteur, Unit of Helicobacter Pathogenesis, CNRS UMR2001, 25-28 Rue du Dr Roux, Paris Cedex 15, 75724, France
5. Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

Source: Iranian Biomedical Journal Published:2023

Abstract

Background: The role of inflammatory cytokines, such as TNF-α and IL-8, in gastric carcinogenesis has been investigated, but their impact remains to be further elucidated. Methods: In this study, we measured the serum concentrations of these cytokines and H. pylori serostatus in dyspeptic patients, presenting with normal mucosa (NM = 53), chronic gastritis (CG = 94), and gastric cancer (GC = 82), by ELISA. Results: Moderate levels of TNF-α were detected in the NM group (19.9 ± 19.5 pg/ml), which were nearly doubled in patients with CG (35.7 ± 28.0 pg/ml) and drastically declined in GC patients (1.8 ± 5.9 pg/ml). The serum levels of IL-8, however, were not statistically different amongst these three groups. Conclusion: TNF-α serum concentration seemed to undergo up-and downregulation, when moving from NM to CG and from CG to GC, respectively. If confirmed in a prospective study, this cytokine can behave as a serum indicator of gastric inflammation and malignant transformation. © 2023, Pasteur Institute of Iran. All rights reserved.

Style	Citing Format
MLA	Alikhani M, et al.. "Alteration in Serum Levels of Tumor Necrosis Factor Alpha Is Associated With Histopathologic Progression of Gastric Cancer." Iranian Biomedical Journal, vol. 27, no. 1, 2023, pp. -.
APA	Alikhani M, Esmaeili M, Tashakoripour M, Mohagheghi MA, Hosseini ME, Touati E, Vosough M, Mohammadi M (2023). Alteration in Serum Levels of Tumor Necrosis Factor Alpha Is Associated With Histopathologic Progression of Gastric Cancer. Iranian Biomedical Journal, 27(1), -.
Chicago	Alikhani M, Esmaeili M, Tashakoripour M, Mohagheghi MA, Hosseini ME, Touati E, Vosough M, Mohammadi M. "Alteration in Serum Levels of Tumor Necrosis Factor Alpha Is Associated With Histopathologic Progression of Gastric Cancer." Iranian Biomedical Journal 27, no. 1 (2023): -.
Harvard	Alikhani M et al. (2023) 'Alteration in Serum Levels of Tumor Necrosis Factor Alpha Is Associated With Histopathologic Progression of Gastric Cancer', Iranian Biomedical Journal, 27(1), pp. -.
Vancouver	Alikhani M, Esmaeili M, Tashakoripour M, Mohagheghi MA, Hosseini ME, Touati E, et al.. Alteration in Serum Levels of Tumor Necrosis Factor Alpha Is Associated With Histopathologic Progression of Gastric Cancer. Iranian Biomedical Journal. 2023;27(1):-.
BibTex	@article{ author = {Alikhani M and Esmaeili M and Tashakoripour M and Mohagheghi MA and Hosseini ME and Touati E and Vosough M and Mohammadi M}, title = {Alteration in Serum Levels of Tumor Necrosis Factor Alpha Is Associated With Histopathologic Progression of Gastric Cancer}, journal = {Iranian Biomedical Journal}, volume = {27}, number = {1}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Alikhani M AU - Esmaeili M AU - Tashakoripour M AU - Mohagheghi MA AU - Hosseini ME AU - Touati E AU - Vosough M AU - Mohammadi M TI - Alteration in Serum Levels of Tumor Necrosis Factor Alpha Is Associated With Histopathologic Progression of Gastric Cancer JO - Iranian Biomedical Journal VL - 27 IS - 1 SP - EP - PY - 2023 ER -

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