Direct Immunofluorescence Results of the Skin Biopsy and Frequency of Systemic Involvement in Children With Henoch-Schonlein Purpura

Direct Immunofluorescence Results of the Skin Biopsy and Frequency of Systemic Involvement in Children With Henoch-Schonlein Purpura Publisher Pubmed

Ataeepour M¹ ; Monajemzadeh M^{2, 3} ; Sadeghi P⁴ ; Ziaee V^{2, 4, 5}

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1. Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran
3. Children's Medical Center, Pediatrics Center of Excellence, Tehran, Iran
4. Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran
5. Pediatric Rheumatology Research Group, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Fetal and Pediatric Pathology Published:2019

Abstract

Objective: Henoch-Schonlein purpura (HSP) is a common vasculitis in children that can present with multi-organ involvement. The aim of this study is to investigate the correlation between direct immunofluorescence (DIF) results and the systemic involvements of the HSP in pediatric patients. Material and Methods: Those HSP patients with leukocytoclastic vasculitis on their biopsies who also had documented immunoglobulin/complement deposition by DIF were included in our study. Their demographic and laboratory data and clinical manifestations were recorded and analyzed. Results: Medical records of 95 patients (1.5–15 years old) were studied. 26.3% of the patients showed renal, 86.3% articular, and 70.3% gastrointestinal involvement. The risk of renal involvement was significantly higher in those with C3 deposition in their skin DIF. IgM deposition was mostly associated with articular involvement. Conclusion: Pediatric HSP patients who had C3 deposition in their skin DIF should be selected for further evaluation regarding HSP nephritis. © 2018, © 2018 Taylor & Francis Group, LLC.

Experts (# of related papers)

Behnaz Bazargani (1)

Mastaneh Moghtaderi (1)

Style	Citing Format
MLA	Ataeepour M, et al.. "Direct Immunofluorescence Results of the Skin Biopsy and Frequency of Systemic Involvement in Children With Henoch-Schonlein Purpura." Fetal and Pediatric Pathology, vol. 38, no. 2, 2019, pp. 121-126.
APA	Ataeepour M, Monajemzadeh M, Sadeghi P, Ziaee V (2019). Direct Immunofluorescence Results of the Skin Biopsy and Frequency of Systemic Involvement in Children With Henoch-Schonlein Purpura. Fetal and Pediatric Pathology, 38(2), 121-126.
Chicago	Ataeepour M, Monajemzadeh M, Sadeghi P, Ziaee V. "Direct Immunofluorescence Results of the Skin Biopsy and Frequency of Systemic Involvement in Children With Henoch-Schonlein Purpura." Fetal and Pediatric Pathology 38, no. 2 (2019): 121-126.
Harvard	Ataeepour M et al. (2019) 'Direct Immunofluorescence Results of the Skin Biopsy and Frequency of Systemic Involvement in Children With Henoch-Schonlein Purpura', Fetal and Pediatric Pathology, 38(2), pp. 121-126.
Vancouver	Ataeepour M, Monajemzadeh M, Sadeghi P, Ziaee V. Direct Immunofluorescence Results of the Skin Biopsy and Frequency of Systemic Involvement in Children With Henoch-Schonlein Purpura. Fetal and Pediatric Pathology. 2019;38(2):121-126.
BibTex	@article{ author = {Ataeepour M and Monajemzadeh M and Sadeghi P and Ziaee V}, title = {Direct Immunofluorescence Results of the Skin Biopsy and Frequency of Systemic Involvement in Children With Henoch-Schonlein Purpura}, journal = {Fetal and Pediatric Pathology}, volume = {38}, number = {2}, pages = {121-126}, year = {2019} }
RIS	TY - JOUR AU - Ataeepour M AU - Monajemzadeh M AU - Sadeghi P AU - Ziaee V TI - Direct Immunofluorescence Results of the Skin Biopsy and Frequency of Systemic Involvement in Children With Henoch-Schonlein Purpura JO - Fetal and Pediatric Pathology VL - 38 IS - 2 SP - 121 EP - 126 PY - 2019 ER -

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