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Relationship Between Ct Volumetric Measurements and Doppler Perfusion Indices in Gastrointestinal Liver Metastasis Publisher Pubmed



Radmard AR1, 2 ; Abrishami A1 ; Gholamrezanezhad A3 ; Kolahdoozan S2 ; Sedighi N1 ; Taheri APH1
Authors
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Authors Affiliations
  1. 1. Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences, North Kargar Ave., Tehran, 14114, Iran
  2. 2. Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, North Kargar Ave., Tehran, 14117-13135, Iran
  3. 3. Department of Radiology, Case Medical Center, Case Western Reserve University, Cleveland, OH, United States

Source: Radiologia Medica Published:2015


Abstract

Purpose: This study investigated how the volume of hepatic metastatic lesions can affect liver haemodynamics and whether these perfusion parameters may help to differentiate benign and malignant liver lesions.; Materials and methods: The Doppler perfusion index (DPI the ratio of arterial to total liver blood flow) was measured in 46 patients aged 29–83 years, exhibiting up to four focal hyperechoic liver lesions at ultrasound examination. They comprised histopathologically proven liver metastasis of colorectal (19 cases) and gastric (10 cases) adenocarcinoma without local recurrence at the site of the previously resected primary tumour, along with 17 subjects with haemangioma. All patients underwent volumetric assessment using multislice computed tomography to calculate total volume of hepatic lesions.; Results: The mean DPI of patients with colorectal (36 ± 2 %) and gastric (39 ± 6 %) metastasis was significantly higher than those with haemangioma (14 ± 2 %) (both p < 0.001), whereas metastatic groups did not exhibit any difference in terms of mean DPI. Statistically significant correlations were found between DPI values and calculated total volume of lesions in patients with colorectal and gastric metastasis (r = 0.55, p = 0.01 and r = 0.85, p = 0.002, respectively) while this correlation was not demonstrated in the haemangioma group. Simple linear regression analysis revealed that every 1 cm3 increment in total volume of metastatic lesions increased DPI by 0.2 % [95 % confidence interval (CI) 0.1–0.3, p = 0.001].; Conclusion: Doppler perfusion index alterations are directly correlated with total volume of metastatic deposits, and DPI measurement can be a valuable method to distinguish haemangioma from hyperechoic colorectal and gastric metastatic lesions. © 2014, Italian Society of Medical Radiology.