Isolation and Purification of Apigenin, Quercetin and Apigenin 7-O-Glycoside From Apium Graveolens L., Petroselinum Crispum (Mill.) Fuss, Allium Cepa L., Respectively; [گلیکوزید به ترتیب از گیاهان کرفس،-O- خالصسازی و شناسایی آپیژنین، کوئرستین، آپیژنین 7جعفری و پیاز]

Isolation and Purification of Apigenin, Quercetin and Apigenin 7-O-Glycoside From Apium Graveolens L., Petroselinum Crispum (Mill.) Fuss, Allium Cepa L., Respectively; [گلیکوزید به ترتیب از گیاهان کرفس،-O- خالصسازی و شناسایی آپیژنین، کوئرستین، آپیژنین 7جعفری و پیاز] Publisher

Tavakoli S¹ ; Khalighisigaroodi F¹ ; Dehaghi NK^{2, 3} ; Yaghoobi M⁴ ; Hajiaghaee R¹ ; Gholami A⁵ ; Ghafarzadegan R¹

Show Affiliations

1. Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
2. Evidence-Based Phytotherapy & Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran
3. Department of Pharmacognosy, School of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran
4. Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran
5. Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Medicinal Plants Published:2022

Abstract

Background: Flavonoids, a group of natural substances, are found in flowers, fruits, roots and stems. These natural products are well known for their health-beneficial effects. Hence, isolation and purifying of flavonoids from the ingredients is worthwhile. Flavonoids are now considered indispensable in various nutraceutical, pharmaceutical, medicinal and cosmetic applications. Apigenin, quercetin, and apigenin-7-O-glycoside have therapeutic properties that these two are in the flavonoid group. Objectives: In this study, apigenin, quercetin, and apigenin 7-O-glycoside were purified by column chromatography and identified by NMR and HPLC UV-visible techniques. Methods: Total extracts of three plants (Apium graveolens, Petroselinum crispum, Allium cepa) were divided into different solvent fractions. Column chromatography is used to purify these fractions. Finally, 1H-NMR, 13C-NMR, and mass spectrometry techniques were used for identification. Also, the HPLC technique was used for identifying these compounds and standardized. Results: In the present work, apigenin was extracted from ethyl acetate fraction of Apium graveolens seeds. High purity of apigenin 7-O-glycoside isolated from the butanol fraction of Petroselinum crispum aerial parts. Also, ethyl acetate fraction isolated quercetin from the Allium cepa. Identification of the data obtained from 1H-NMR and 13C-NMR, which were proofed by comparison with the sources of purified compounds. Conclusion: The methods used in this research were able to produce these three compounds with a high percentage of purity to be used in industry as standards. © 2020. Open access. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/)

2. Induction of Cancer Cell Death by Apigenin: A Review on Different Cell Death Pathways, Mini-Reviews in Medicinal Chemistry (2023)

3. The Influence of Apigenin on Cellular Responses to Radiation: From Protection to Sensitization, BioFactors (2025)

Experts (# of related papers)

Roodabeh Bahramsoltani (1)

Azadeh Manayi (1)

Style	Citing Format
MLA	Tavakoli S, et al.. "Isolation and Purification of Apigenin, Quercetin and Apigenin 7-O-Glycoside From Apium Graveolens L., Petroselinum Crispum (Mill.) Fuss, Allium Cepa L., Respectively; [گلیکوزید به ترتیب از گیاهان کرفس،-O- خالصسازی و شناسایی آپیژنین، کوئرستین، آپیژنین 7جعفری و پیاز]." Journal of Medicinal Plants, vol. 21, no. 83, 2022, pp. 72-86.
APA	Tavakoli S, Khalighisigaroodi F, Dehaghi NK, Yaghoobi M, Hajiaghaee R, Gholami A, Ghafarzadegan R (2022). Isolation and Purification of Apigenin, Quercetin and Apigenin 7-O-Glycoside From Apium Graveolens L., Petroselinum Crispum (Mill.) Fuss, Allium Cepa L., Respectively; [گلیکوزید به ترتیب از گیاهان کرفس،-O- خالصسازی و شناسایی آپیژنین، کوئرستین، آپیژنین 7جعفری و پیاز]. Journal of Medicinal Plants, 21(83), 72-86.
Chicago	Tavakoli S, Khalighisigaroodi F, Dehaghi NK, Yaghoobi M, Hajiaghaee R, Gholami A, Ghafarzadegan R. "Isolation and Purification of Apigenin, Quercetin and Apigenin 7-O-Glycoside From Apium Graveolens L., Petroselinum Crispum (Mill.) Fuss, Allium Cepa L., Respectively; [گلیکوزید به ترتیب از گیاهان کرفس،-O- خالصسازی و شناسایی آپیژنین، کوئرستین، آپیژنین 7جعفری و پیاز]." Journal of Medicinal Plants 21, no. 83 (2022): 72-86.
Harvard	Tavakoli S et al. (2022) 'Isolation and Purification of Apigenin, Quercetin and Apigenin 7-O-Glycoside From Apium Graveolens L., Petroselinum Crispum (Mill.) Fuss, Allium Cepa L., Respectively; [گلیکوزید به ترتیب از گیاهان کرفس،-O- خالصسازی و شناسایی آپیژنین، کوئرستین، آپیژنین 7جعفری و پیاز]', Journal of Medicinal Plants, 21(83), pp. 72-86.
Vancouver	Tavakoli S, Khalighisigaroodi F, Dehaghi NK, Yaghoobi M, Hajiaghaee R, Gholami A, et al.. Isolation and Purification of Apigenin, Quercetin and Apigenin 7-O-Glycoside From Apium Graveolens L., Petroselinum Crispum (Mill.) Fuss, Allium Cepa L., Respectively; [گلیکوزید به ترتیب از گیاهان کرفس،-O- خالصسازی و شناسایی آپیژنین، کوئرستین، آپیژنین 7جعفری و پیاز]. Journal of Medicinal Plants. 2022;21(83):72-86.
BibTex	@article{ author = {Tavakoli S and Khalighisigaroodi F and Dehaghi NK and Yaghoobi M and Hajiaghaee R and Gholami A and Ghafarzadegan R}, title = {Isolation and Purification of Apigenin, Quercetin and Apigenin 7-O-Glycoside From Apium Graveolens L., Petroselinum Crispum (Mill.) Fuss, Allium Cepa L., Respectively; [گلیکوزید به ترتیب از گیاهان کرفس،-O- خالصسازی و شناسایی آپیژنین، کوئرستین، آپیژنین 7جعفری و پیاز]}, journal = {Journal of Medicinal Plants}, volume = {21}, number = {83}, pages = {72-86}, year = {2022} }
RIS	TY - JOUR AU - Tavakoli S AU - Khalighisigaroodi F AU - Dehaghi NK AU - Yaghoobi M AU - Hajiaghaee R AU - Gholami A AU - Ghafarzadegan R TI - Isolation and Purification of Apigenin, Quercetin and Apigenin 7-O-Glycoside From Apium Graveolens L., Petroselinum Crispum (Mill.) Fuss, Allium Cepa L., Respectively; [گلیکوزید به ترتیب از گیاهان کرفس،-O- خالصسازی و شناسایی آپیژنین، کوئرستین، آپیژنین 7جعفری و پیاز] JO - Journal of Medicinal Plants VL - 21 IS - 83 SP - 72 EP - 86 PY - 2022 ER -

Style

Citing Format

MLA

Tavakoli S, et al.. "Isolation and Purification of Apigenin, Quercetin and Apigenin 7-O-Glycoside From Apium Graveolens L., Petroselinum Crispum (Mill.) Fuss, Allium Cepa L., Respectively; [گلیکوزید به ترتیب از گیاهان کرفس،-O- خالصسازی و شناسایی آپیژنین، کوئرستین، آپیژنین 7جعفری و پیاز]." Journal of Medicinal Plants, vol. 21, no. 83, 2022, pp. 72-86.

APA

Tavakoli S, Khalighisigaroodi F, Dehaghi NK, Yaghoobi M, Hajiaghaee R, Gholami A, Ghafarzadegan R (2022). Isolation and Purification of Apigenin, Quercetin and Apigenin 7-O-Glycoside From Apium Graveolens L., Petroselinum Crispum (Mill.) Fuss, Allium Cepa L., Respectively; [گلیکوزید به ترتیب از گیاهان کرفس،-O- خالصسازی و شناسایی آپیژنین، کوئرستین، آپیژنین 7جعفری و پیاز]. Journal of Medicinal Plants, 21(83), 72-86.

Chicago

Tavakoli S, Khalighisigaroodi F, Dehaghi NK, Yaghoobi M, Hajiaghaee R, Gholami A, Ghafarzadegan R. "Isolation and Purification of Apigenin, Quercetin and Apigenin 7-O-Glycoside From Apium Graveolens L., Petroselinum Crispum (Mill.) Fuss, Allium Cepa L., Respectively; [گلیکوزید به ترتیب از گیاهان کرفس،-O- خالصسازی و شناسایی آپیژنین، کوئرستین، آپیژنین 7جعفری و پیاز]." Journal of Medicinal Plants 21, no. 83 (2022): 72-86.

Harvard

Tavakoli S et al. (2022) 'Isolation and Purification of Apigenin, Quercetin and Apigenin 7-O-Glycoside From Apium Graveolens L., Petroselinum Crispum (Mill.) Fuss, Allium Cepa L., Respectively; [گلیکوزید به ترتیب از گیاهان کرفس،-O- خالصسازی و شناسایی آپیژنین، کوئرستین، آپیژنین 7جعفری و پیاز]', Journal of Medicinal Plants, 21(83), pp. 72-86.

Vancouver

Tavakoli S, Khalighisigaroodi F, Dehaghi NK, Yaghoobi M, Hajiaghaee R, Gholami A, et al.. Isolation and Purification of Apigenin, Quercetin and Apigenin 7-O-Glycoside From Apium Graveolens L., Petroselinum Crispum (Mill.) Fuss, Allium Cepa L., Respectively; [گلیکوزید به ترتیب از گیاهان کرفس،-O- خالصسازی و شناسایی آپیژنین، کوئرستین، آپیژنین 7جعفری و پیاز]. Journal of Medicinal Plants. 2022;21(83):72-86.

BibTex

@article{ author = {Tavakoli S and Khalighisigaroodi F and Dehaghi NK and Yaghoobi M and Hajiaghaee R and Gholami A and Ghafarzadegan R}, title = {Isolation and Purification of Apigenin, Quercetin and Apigenin 7-O-Glycoside From Apium Graveolens L., Petroselinum Crispum (Mill.) Fuss, Allium Cepa L., Respectively; [گلیکوزید به ترتیب از گیاهان کرفس،-O- خالصسازی و شناسایی آپیژنین، کوئرستین، آپیژنین 7جعفری و پیاز]}, journal = {Journal of Medicinal Plants}, volume = {21}, number = {83}, pages = {72-86}, year = {2022} }

RIS

TY - JOUR
AU - Tavakoli S
AU - Khalighisigaroodi F
AU - Dehaghi NK
AU - Yaghoobi M
AU - Hajiaghaee R
AU - Gholami A
AU - Ghafarzadegan R
TI - Isolation and Purification of Apigenin, Quercetin and Apigenin 7-O-Glycoside From Apium Graveolens L., Petroselinum Crispum (Mill.) Fuss, Allium Cepa L., Respectively; [گلیکوزید به ترتیب از گیاهان کرفس،-O- خالصسازی و شناسایی آپیژنین، کوئرستین، آپیژنین 7جعفری و پیاز]
JO - Journal of Medicinal Plants
VL - 21
IS - 83
SP - 72
EP - 86
PY - 2022
ER -

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