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The Presence of Abnormal Septal Motion on Echocardiography Is a Predictor of Abnormal Cardiac Magnetic Resonance in Systemic Sclerosis Publisher Pubmed



Javadynejad Z1 ; Jamshidi AR1 ; Aletaha A2 ; Qorbani M3 ; Kavosi H1 ; Soltani A2 ; Gharibdoost F1
Authors
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Authors Affiliations
  1. 1. Rheumatology Research Centre, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Evidence-Based Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Epidemiology and Biostatistics, Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran

Source: Rheumatology (United Kingdom) Published:2024


Abstract

Objectives: We aimed to perform a comprehensive analysis of the ECG, two-dimensional echocardiography (2DE) and cardiac MRI (CMR) findings in patients with systemic sclerosis (SSc), and also to investigate correlations between CMR findings and some ECG and echocardiography (ECHO) results. Methods: We retrospectively analysed data from patients with SSc who were regularly seen at our outpatient referral centre, all assessed with ECG, Doppler ECHO and CMR. Results: Ninety-three patients were included; mean (s.d.) age of 48.5 (10.3) years, 86% female, 52% diffuse SSc. Eighty-four (90%) of the patients had sinus rhythm. The most common ECG finding was the left anterior fascicular block, recorded in 26 patients (28%). The abnormal septal motion (ASM) was found in 43 (46%) patients on ECHO. Myocardial involvement (inflammation or fibrosis), as assessed by multiparametric CMR, was present in >50% of our patients. The age- and sex-adjusted model showed that ASM on ECHO increased significantly the odds of increased extracellular volume [odds ratio (OR) 4.43, 95% CI 1.73, 11.38], increased T1 Relaxation time (OR 2.67, 95% CI 1.09, 6.54), increased T2 Relaxation time (OR 2.56, 95% CI 1.05, 6.22), increased signal intensity ratio in T2-weighted imaging (OR 2.56, 95% CI 1.05, 6.22), presence of late gadolinium enhancement (OR 3.85, 95% CI 1.52, 9.76) and mid-wall fibrosis (OR 3.64, 95% CI 1.48, 8.96). Conclusion: This study indicates that the presence of ASM on ECHO is a predictor of abnormal CMR in SSc patients, and a precise assessment of ASM may serve as an important point for selecting the patients that should be evaluated by CMR for early detection of myocardial involvement. © 2023 The Author(s). Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.