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Zearalenone, an Estrogenic Component, in Bovine Milk, Amount and Detection Method; a Systematic Review and Meta-Analysis Publisher



Ghanati K1 ; Basaran B2 ; Abedini A3 ; Akbariadergani B4 ; Akbari N5 ; Sadighara P5
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Authors Affiliations
  1. 1. Department of food science and Technology, National Nutrition and Food Technology Research Institute (NNFTRI) and Food safety research center, Shahid Beheshti University of medical sciences, Tehran, Iran
  2. 2. Department of Nutrition and Dietetics, Faculty of Health Sciences, Recep Tayyip Erdogan University, Rize, 53100, Turkey
  3. 3. Student Research Committee, Department of Food Science and Technology, Faculty of Nutrition Science and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Water Safety Research Center, Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran
  5. 5. Department of Environmental Health, Food Safety Division, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Toxicology Reports Published:2024


Abstract

Zearalenone (ZEN) and its metabolites are a potent component with estrogenic potential that can enter milk. ZEN and its metabolites have the ability to disturb the function of endocrine glands. The aim of this systematic review was to estimate the level of ZEN and its metabolites in milk. This study was performed with these keywords; zearalenone, ZEN, bovine milk, ruminant milk, milk, dairy products, and milk product in various databases. 946 manuscripts were collected from databases and at the end, 17 manuscripts were reviewed according to the inclusion criteria. ZEN was identified in 59 % of studies. The most common methods of analysis were UHPLC, HPLC and ELISA. Meta-analysis was performed with CMA (Comprehensive Meta-Analysis) software. No publication bias was observed in meta- analysis. But, heterogeneity was recorded between studies. The measurement method was identified as one of the sources of heterogeneity through meta-regression tests and subgroup analysis. Furthermore, in meta- analysis test, the total estimate of milk contamination with this mycotoxin was 0.036±0.017 µg/L. So far, the permissible limit for this compound in milk has not been announced, but these compounds have the ability to disturb the endocrine glands in low amounts. Therefore, it is necessary to regularly measure and control this mycotoxin and its metabolite in milk with valid methods. © 2024 The Authors
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