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Association of Il4 Single-Nucleotide Polymorphisms With Febrile Seizures Publisher Pubmed



Zareshahabadi A1 ; Soltani S2 ; Ashrafi MR4 ; Shahrokhi A4, 5 ; Zoghi S2 ; Pourakbari B6 ; Zamani GR4 ; Mohammadi M4 ; Rezaei N1, 2
Authors
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Authors Affiliations
  1. 1. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Molecular Immunology Research Center
  3. 3. and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Pediatric Neurorehabilitation Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
  6. 6. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Child Neurology Published:2015


Abstract

As of importance of interleukin-4 (IL-4) in inhibiting the production of proinflammatory cytokines, the IL4 gene polymorphisms were investigated in patients with febrile seizure. This association has not been investigated yet, except 1 study which has been done in Japanese population. Eighty-two patients with febrile seizure were enrolled in this study, compared with 139 controls. The allele and genotype frequency of 3 single-nucleotide polymorphisms of IL4 gene were determined. Frequency of the IL4-590/C allele in the patient group was significantly higher than in the control group (P <.0001). Frequency of the following genotypes was significantly lower in patients compared to controls: IL-4 (-590) TC (P =.0001) and IL-4 (-33) TC (P =.001). The most frequent IL-4 haplotype in the patient group was TCC (P =.00) haplotype. In contrast, frequencies of GCC (P =.01), TTT (P =.009), and TTC (P =.0007) haplotypes were significantly lower in febrile seizure patients. Certain alleles, genotypes, and haplotypes in the IL4 gene were overrepresented in Iranian patients with febrile seizure, which could predispose individuals to this disease, and further investigations in other ethnicities are required. © The Author(s) 2014.
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