A Rare Case of Primary Cutaneous Cd4+ Small/Medium Size T-Cell Lymphoproliferative Disorder Responding to Rituximab

A Rare Case of Primary Cutaneous Cd4+ Small/Medium Size T-Cell Lymphoproliferative Disorder Responding to Rituximab Publisher

Alzahawi S¹ ; Masoomi S¹ ; Ghanadan A² ; Sadeghi Y¹ ; Daneshpazhooh M^{1, 3} ; Mahmoudi H^{1, 3}

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1. Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran
2. Department of Dermatopathology, Razi Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran
3. Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Case Reports in Dermatology Published:2025

Abstract

Introduction: Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder is a rare lymphoproliferative disorder (PCS-TCLPD) characterized by a solitary erythematous plaque or nodule on the face, neck, or upper trunk with a favorable outcome. Very rarely, multiple plaques or masses may be seen in which precise evaluation should be performed to exclude other primary cutaneous lymphoma. Case Presentation: Here we report a rare case of recalcitrant primary cutaneous small-/ medium-sized CD4+ lymphoproliferative disorder in a 55-year-oldmale patient who responded well to rituximab injection but had recurrence after 1 year from the injections. Conclusion: Aggressive treatment is avoided in solitary lesions of PCS-TCLPD, but multiple lesions with no response to the conventional modalities may need more sophisticated management, including anti-CD20 rituximab. © 2025 The Author(s).

Style	Citing Format
MLA	Alzahawi S, et al.. "A Rare Case of Primary Cutaneous Cd4+ Small/Medium Size T-Cell Lymphoproliferative Disorder Responding to Rituximab." Case Reports in Dermatology, vol. , no. , 2025, pp. 150-156.
APA	Alzahawi S, Masoomi S, Ghanadan A, Sadeghi Y, Daneshpazhooh M, Mahmoudi H (2025). A Rare Case of Primary Cutaneous Cd4+ Small/Medium Size T-Cell Lymphoproliferative Disorder Responding to Rituximab. Case Reports in Dermatology, (), 150-156.
Chicago	Alzahawi S, Masoomi S, Ghanadan A, Sadeghi Y, Daneshpazhooh M, Mahmoudi H. "A Rare Case of Primary Cutaneous Cd4+ Small/Medium Size T-Cell Lymphoproliferative Disorder Responding to Rituximab." Case Reports in Dermatology , no. (2025): 150-156.
Harvard	Alzahawi S et al. (2025) 'A Rare Case of Primary Cutaneous Cd4+ Small/Medium Size T-Cell Lymphoproliferative Disorder Responding to Rituximab', Case Reports in Dermatology, (), pp. 150-156.
Vancouver	Alzahawi S, Masoomi S, Ghanadan A, Sadeghi Y, Daneshpazhooh M, Mahmoudi H. A Rare Case of Primary Cutaneous Cd4+ Small/Medium Size T-Cell Lymphoproliferative Disorder Responding to Rituximab. Case Reports in Dermatology. 2025;():150-156.
BibTex	@article{ author = {Alzahawi S and Masoomi S and Ghanadan A and Sadeghi Y and Daneshpazhooh M and Mahmoudi H}, title = {A Rare Case of Primary Cutaneous Cd4+ Small/Medium Size T-Cell Lymphoproliferative Disorder Responding to Rituximab}, journal = {Case Reports in Dermatology}, volume = {}, number = {}, pages = {150-156}, year = {2025} }
RIS	TY - JOUR AU - Alzahawi S AU - Masoomi S AU - Ghanadan A AU - Sadeghi Y AU - Daneshpazhooh M AU - Mahmoudi H TI - A Rare Case of Primary Cutaneous Cd4+ Small/Medium Size T-Cell Lymphoproliferative Disorder Responding to Rituximab JO - Case Reports in Dermatology VL - IS - SP - 150 EP - 156 PY - 2025 ER -

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