Growth Inhibition of Mda-Mb-231 Cell Line by Peptides Designed Based on Upa

Growth Inhibition of Mda-Mb-231 Cell Line by Peptides Designed Based on Upa Pubmed

Tarighi P^{1, 2, 3, 4, 5} ; Khorramizadeh M^{1, 2, 3, 4, 5} ; Madadkarsobhani A^{1, 2, 3, 4, 5} ; Ostad S^{1, 2, 3, 4, 5} ; Ghahremani M^{1, 2, 3, 4, 5}

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1. Department of Toxicology-Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Iran AND Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Tehran, Iran
2. Department of Toxicology-Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Iran AND Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Tehran, Iran
3. Department of Toxicology-Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Iran AND Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Tehran, Iran
4. Department of Toxicology-Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Iran AND Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Tehran, Iran
5. Department of Toxicology-Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Iran AND Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Tehran, Iran

Source: Acta medica Iranica Published:2015

Abstract

Interaction between urokinase-type plasminogen activator (uPA) and its receptor (uPAR) plays an important role in the progression of numerous cancer types including breast cancer by promoting tumor initiating, proliferation, invasion and metastasis. Hence, disruption of this interaction inhibits their downstream cascades and subsequently tumor growth. For this, we created two series of 8 and 10 amino acids linear peptides, derived from uPA binding region to target uPAR and studied the inhibition of proliferation in MDA-MB-231 cell line. Results revealed that all of the 10-mer peptides inhibited breast cancer cell proliferation significantly with maximum 40% inhibition of 103 peptides. Meanwhile, none of the 8-mer peptides showed significant toxicity. Current results indicate that the linear 10-mer peptides which mimic a small part of a sequence of a binding domain of uPA to uPAR could be exploited to design a novel class of anti-cancer agents.

Style	Citing Format
MLA	Tarighi P, et al.. "Growth Inhibition of Mda-Mb-231 Cell Line by Peptides Designed Based on Upa." Acta medica Iranica, vol. 53, no. 7, 2015, pp. 403-407.
APA	Tarighi P, Khorramizadeh M, Madadkarsobhani A, Ostad S, Ghahremani M (2015). Growth Inhibition of Mda-Mb-231 Cell Line by Peptides Designed Based on Upa. Acta medica Iranica, 53(7), 403-407.
Chicago	Tarighi P, Khorramizadeh M, Madadkarsobhani A, Ostad S, Ghahremani M. "Growth Inhibition of Mda-Mb-231 Cell Line by Peptides Designed Based on Upa." Acta medica Iranica 53, no. 7 (2015): 403-407.
Harvard	Tarighi P et al. (2015) 'Growth Inhibition of Mda-Mb-231 Cell Line by Peptides Designed Based on Upa', Acta medica Iranica, 53(7), pp. 403-407.
Vancouver	Tarighi P, Khorramizadeh M, Madadkarsobhani A, Ostad S, Ghahremani M. Growth Inhibition of Mda-Mb-231 Cell Line by Peptides Designed Based on Upa. Acta medica Iranica. 2015;53(7):403-407.
BibTex	@article{ author = {Tarighi P and Khorramizadeh M and Madadkarsobhani A and Ostad S and Ghahremani M}, title = {Growth Inhibition of Mda-Mb-231 Cell Line by Peptides Designed Based on Upa}, journal = {Acta medica Iranica}, volume = {53}, number = {7}, pages = {403-407}, year = {2015} }
RIS	TY - JOUR AU - Tarighi P AU - Khorramizadeh M AU - Madadkarsobhani A AU - Ostad S AU - Ghahremani M TI - Growth Inhibition of Mda-Mb-231 Cell Line by Peptides Designed Based on Upa JO - Acta medica Iranica VL - 53 IS - 7 SP - 403 EP - 407 PY - 2015 ER -

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