An International Study Presenting a Federated Learning Ai Platform for Pediatric Brain Tumors

An International Study Presenting a Federated Learning Ai Platform for Pediatric Brain Tumors Publisher Pubmed

Lee EH^{1, 2} ; Han M^{1, 3} ; Wright J⁴ ; Kuwabara M⁵ ; Mevorach J⁶ ; Fu G⁶ ; Choudhury O⁶ ; Ratan U⁶ ; Zhang M¹ ; Wagner MW⁷ ; Goetti R⁸ ; Toescu S⁹ ; Perreault S¹⁰ ; Dogan H¹¹ Show All Authors

Lee EH^{1, 2}
Han M^{1, 3}
Wright J⁴
Kuwabara M⁵
Mevorach J⁶
Fu G⁶
Choudhury O⁶
Ratan U⁶
Zhang M¹
Wagner MW⁷
Goetti R⁸
Toescu S⁹
Perreault S¹⁰
Dogan H¹¹
Altinmakas E¹²
Mohammadzadeh M¹³
Szymanski KA^{5, 14}
Campen CJ¹⁵
Lai H¹⁶
Eghbal A¹⁶
Radmanesh A^{17, 35}
Mankad K⁹
Aquilina K⁹
Said M¹⁸
Vossough A³
Oztekin O^{19, 36}
Ertlwagner B²⁰
Poussaint T²¹
Thompson EM²²
Ho CY²⁴
Jaju A⁵
Curran J⁵
Ramaswamy V²⁶
Cheshier SH²⁷
Grant GA²²
Wong SS²⁸
Moseley ME²
Lober RM²⁹
Wilms M^{30, 31, 32}
Forkert ND^{32, 33}
Vitanza NA³⁴
Miller JH⁵
Prolo LM¹
Yeom KW^{1, 5}

Show Affiliations

1. Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, United States
2. Department of Radiology, Lucas Center, Stanford University, Stanford, CA, United States
3. Department of Neurology, Children’s Hospital of Philadelphia, Philadelphia, PA, United States
4. Department of Radiology, Seattle Children’s Hospital, Seattle, WA, United States
5. Department of Radiology, Phoenix Children’s Hospital, Phoenix, AZ, United States
6. Amazon Web Services, Seattle, WA, United States
7. Department of Diagnostic and Interventional Neuroradiology, University Hospital Augsburg, Augsburg, Germany
8. Department of Medical Imaging, The Children’s Hospital at Westmead, Sydney, NSW, Australia
9. Great Ormond Street Hospital for Children, London, United Kingdom
10. Division of Child Neurology, Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, Universite de Montreal, Montreal, QC, Canada
11. Department of Radiology, Koc University School of Medicine, Istanbul, Turkey
12. Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States
13. Department of Radiology, Tehran University of Medical Sciences, Tehran, Iran
14. Creighton University School of Medicine—Phoenix Regional Campus, Phoenix, AZ, United States
15. Department of Neurology, Lucile Packard Children’s Hospital, Stanford University Medical School, Palo Alto, CA, United States
16. Department of Radiology, Children’s Hospital of Orange County, Orange, CA, United States
17. Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States
18. Radiology Department, Centre International Carthage Medicale, Monastir, Tunisia
19. Department of Neuroradiology, Tepecik Education and Research Hospital, Izmir, Turkey
20. Department of Diagnostic and Interventional Radiology, The Hospital for Sick Children, Toronto, ON, Canada
21. Department of Radiology, Boston Children’s Hospital, Boston, MA, United States
22. Department of Neurosurgery, Duke Children’s Hospital & amp
23. Health Center, Durham, NC, United States
24. Department of Radiology & amp
25. Imaging Sciences, Riley Children’s Hospital, Indianapolis, IN, United States
26. Division of Haematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada
27. Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, UT, United States
28. Department of Electrical Engineering, Stanford University, Stanford, CA, United States
29. Division of Neurosurgery, Dayton Children’s Hospital, Dayton, OH, United States
30. Departments of Pediatrics, Community Health Sciences, and Radiology, University of Calgary, Calgary, AB, Canada
31. Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB, Canada
32. Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
33. Departments of Radiology and Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
34. Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute, Seattle, WA, United States
35. Kaiser Los Angeles, Los Angeles, CA, United States
36. Hamad Medical Corporation, Doha, Qatar

Source: Nature Communications Published:2024

Abstract

While multiple factors impact disease, artificial intelligence (AI) studies in medicine often use small, non-diverse patient cohorts due to data sharing and privacy issues. Federated learning (FL) has emerged as a solution, enabling training across hospitals without direct data sharing. Here, we present FL-PedBrain, an FL platform for pediatric posterior fossa brain tumors, and evaluate its performance on a diverse, realistic, multi-center cohort. Pediatric brain tumors were targeted due to the scarcity of such datasets, even in tertiary care hospitals. Our platform orchestrates federated training for joint tumor classification and segmentation across 19 international sites. FL-PedBrain exhibits less than a 1.5% decrease in classification and a 3% reduction in segmentation performance compared to centralized data training. FL boosts segmentation performance by 20 to 30% on three external, out-of-network sites. Finally, we explore the sources of data heterogeneity and examine FL robustness in real-world scenarios with data imbalances. © The Author(s) 2024.

Style	Citing Format
MLA	Lee EH, et al.. "An International Study Presenting a Federated Learning Ai Platform for Pediatric Brain Tumors." Nature Communications, vol. 15, no. 1, 2024, pp. -.
APA	Lee EH, Han M, Wright J, Kuwabara M, Mevorach J, Fu G, Choudhury O, Ratan U, Zhang M, Wagner MW, Goetti R, Toescu S, Perreault S, Dogan H, Altinmakas E, Mohammadzadeh M, Szymanski KA, Campen CJ, Lai H, ... Yeom KW (2024). An International Study Presenting a Federated Learning Ai Platform for Pediatric Brain Tumors. Nature Communications, 15(1), -.
Chicago	Lee EH, Han M, Wright J, Kuwabara M, Mevorach J, Fu G, Choudhury O, et al.. "An International Study Presenting a Federated Learning Ai Platform for Pediatric Brain Tumors." Nature Communications 15, no. 1 (2024): -.
Harvard	Lee EH et al. (2024) 'An International Study Presenting a Federated Learning Ai Platform for Pediatric Brain Tumors', Nature Communications, 15(1), pp. -.
Vancouver	Lee EH, Han M, Wright J, Kuwabara M, Mevorach J, Fu G, et al.. An International Study Presenting a Federated Learning Ai Platform for Pediatric Brain Tumors. Nature Communications. 2024;15(1):-.
BibTex	@article{ author = {Lee EH and Han M and Wright J and Kuwabara M and Mevorach J and Fu G and Choudhury O and Ratan U and Zhang M and Wagner MW and Goetti R and Toescu S and Perreault S and Dogan H and Altinmakas E and Mohammadzadeh M and Szymanski KA and Campen CJ and Lai H and Eghbal A and Radmanesh A and Mankad K and Aquilina K and Said M and Vossough A and Oztekin O and Ertlwagner B and Poussaint T and Thompson EM and Ho CY and Jaju A and Curran J and Ramaswamy V and Cheshier SH and Grant GA and Wong SS and Moseley ME and Lober RM and Wilms M and Forkert ND and Vitanza NA and Miller JH and Prolo LM and Yeom KW}, title = {An International Study Presenting a Federated Learning Ai Platform for Pediatric Brain Tumors}, journal = {Nature Communications}, volume = {15}, number = {1}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Lee EH AU - Han M AU - Wright J AU - Kuwabara M AU - Mevorach J AU - Fu G AU - Choudhury O AU - Ratan U AU - Zhang M AU - Wagner MW AU - Goetti R AU - Toescu S AU - Perreault S AU - Dogan H AU - Altinmakas E AU - Mohammadzadeh M AU - Szymanski KA AU - Campen CJ AU - Lai H AU - Eghbal A AU - Radmanesh A AU - Mankad K AU - Aquilina K AU - Said M AU - Vossough A AU - Oztekin O AU - Ertlwagner B AU - Poussaint T AU - Thompson EM AU - Ho CY AU - Jaju A AU - Curran J AU - Ramaswamy V AU - Cheshier SH AU - Grant GA AU - Wong SS AU - Moseley ME AU - Lober RM AU - Wilms M AU - Forkert ND AU - Vitanza NA AU - Miller JH AU - Prolo LM AU - Yeom KW TI - An International Study Presenting a Federated Learning Ai Platform for Pediatric Brain Tumors JO - Nature Communications VL - 15 IS - 1 SP - EP - PY - 2024 ER -

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Abstract