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Synthesis of Novel Phthalazino[1,2-B]Quinazolinedione Derivatives: Efficient and Practical Reaction of 2-Amino-N′-Arylbenzohydrazides and 2-Formylbenzoic Acids Publisher



Arastehfard Z1 ; Dilmaghani KA1 ; Saeedi M2, 3 ; Mahdavi M4 ; Shafiee A5
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Faculty of Sciences, Urmia University, Urmia, Iran
  2. 2. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Helvetica Chimica Acta Published:2016


Abstract

This work reported the synthesis of novel phthalazino[1,2-b]quinazolinedione derivatives through the reaction of 2-amino-N′-arylbenzohydrazides and 2-formylbenzoic acids in the presence of TsOH in EtOH under reflux conditions. © 2016 Wiley-VHCA AG, Zurich