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Effects of Remote Ischemic Preconditioning on Antioxidant Capacity and Lipid Peroxidation in Patients Undergoing Coronary Artery Bypass Grafting in Tehran Heart Center



Mehrabanian M1 ; Firoozabadi MD1 ; Gorjipour F2 ; Soltaninia H1 ; Nooralishahi B1 ; Rahab M3 ; Mohseni M4
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Authors Affiliations
  1. 1. Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Anesthesiology, Iran University of Medical Sciences, Tehran, Iran

Source: Iranian Heart Journal Published:2023

Abstract

Background: Remote ischemic preconditioning (RIPC) may improve outcomes in ischemia/reperfusion injury (IRI) by improving antioxidant defense. We investigated total antioxidant capacity (TAC) and malondialdehyde (MDA) content as markers of lipid peroxidation. Methods: The present randomized clinical trial allocated 50 coronary artery bypass graft (CABG) patients with cardiopulmonary bypass at Tehran Heart Center to 2 groups: RIPC and control (25 patients each). Clinical biochemistry parameters, TAC, and MDA were measured at 3 time points: post-anesthesia induction (before skin incision), immediately post-CPB, and 24 hours post-ICU admission. Results: Increased transfusions of packed cells in the ICU and higher plasma MDA levels at post-CPB were observed in the control group. Additionally, significantly higher plasma TAC levels were observed at 24 hours post-ICU in the RIPC group. Conclusions: RIPC protects against IRI in CABG on CPB by reducing lipid peroxidation and elevating antioxidant defense. RIPC could be integrated into CABG to reduce IRI adverse outcomes. © 2023, Iranian Heart Association. All rights reserved.
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