The Role of Histology on the Outcome of Sinonasal Carcinomas Treated With Radiotherapy: A Single Institution Experience Publisher

Summary: Histological types of sinonasal cancer show varying recurrence rates post-radiotherapy, suggesting tailored treatment may be essential. Is individualized care the future? #CancerResearch #SinonasalCarcinoma

Kazemian A^{1, 2} ; Farazmand B² ; Taherioun M³ ; Razmkhah M³ ; Shirkhoda M⁴ ; Jalaeefar A⁴ ; Garajei A^{5, 6} ; Jafari M⁷ ; Heidari F⁸ ; Aghili M^{2, 3} ; Ghalehtaki R^{2, 3}
Source: Radiation Oncology Journal Published:2024

Abstract

Purpose: Sinonasal malignancies are a rare group of head and neck cancers. We aimed to report the oncological outcomes based on histological types in patients who underwent radiotherapy. Materials and Methods: In this single-institution study, we retrospectively retrieved and analyzed data of patients with sinonasal carcinomas who underwent radiotherapy during 2011–2016 as part of their treatment. The 3-year rate of local, regional, and distant recurrences, and overall survival were evaluated according to the histological type. Results: A total of 28 patients were evaluated in this study, the majority of whom were male (60%). Squamous cell carcinoma (SCC), adenoid cystic carcinoma (ACC), and adenocarcinoma (ADC) were found in 15 patients (53.5%), 8 (28.5%), and 5 (18%), respectively. The highest rates of local and regional recurrences were observed in ACC and SCC, respectively. Distant recurrences were numerically more common in ADC. The 3-year OS was 48%, 50%, and 73% in SCC, ADC, and ACC, respectively. Conclusion: Different histopathologies of sinonasal cancer seem to have different patterns of failure, and this may be considered in the treatment approach. © 2024 The Korean Society for Radiation Oncology.