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What Is the Prevalence of Clinically Significant Endoscopic Findings in Subjects With Dyspepsia? Updated Systematic Review and Meta-Analysis Publisher Pubmed



Nasserimoghaddam S1, 2 ; Mousavian AH1 ; Kasaeian A1, 3, 4 ; Kanno T5, 6 ; Yuan Y7 ; Ford AC8, 9 ; Moayyedi P2, 7
Authors
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Authors Affiliations
  1. 1. Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medicine, Division of Gastroenterology, McMaster University, Hamilton, Canada
  3. 3. Hematology, Oncology and Stem Cell Transplantation Research Center, Research Institute for Oncology, Hematology and Cell Therapy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Inflammation Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
  6. 6. Department of Education and Support for Regional Medicine, Tohoku University Hospital, Sendai, Japan
  7. 7. Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada
  8. 8. Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, United Kingdom
  9. 9. Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, United Kingdom

Source: Clinical Gastroenterology and Hepatology Published:2023


Abstract

Background & Aims: The prevalence of clinically significant endoscopic findings in people with dyspepsia and understanding how symptoms can predict endoscopic pathology can help inform dyspepsia guidelines. We evaluated this in an updated systematic review and meta-analysis. Methods: We searched MEDLINE, EMBASE, Cochrane CENTRAL, and the Cochrane Database of Systematic Reviews from 2010 through to January 2022 to identify relevant articles. Eligible studies enrolled adults from the community, workplace, blood donation or screening clinics, family physician offices, or internal medicine clinics. Studies were required to report prevalence of dyspepsia and perform esophagogastroduodenoscopy (EGD). Prevalence of clinically significant endoscopic findings in subjects with and without dyspepsia was pooled for all studies and compared using odds ratios and 95% confidence intervals (CIs). The data were pooled with those of the 9 studies included in the prior review. Results: Of 511 papers evaluated, 184 reported prevalence of dyspepsia. Fifteen reported prevalence of endoscopic findings among 41,763 participants (40.4% with dyspepsia). Erosive esophagitis was the most common abnormality (pooled prevalence, 11.0%; 95% CI, 8.9%–13.2%) followed by peptic ulcer (pooled prevalence, 4.4%; 95% CI, 2.5%–6.7%). The only finding encountered more frequently in individuals with dyspepsia, compared with those without, was peptic ulcer (odds ratio, 1.61; 95% CI, 1.08–2.39). More than 85% of EGDs were completely normal. Gastroesophageal cancer was rare (<0.4%) and equally prevalent among those with and without dyspepsia. Conclusions: Erosive esophagitis was the most common clinically significant finding at EGD, whereas gastroesophageal cancers were rare. Most pathology, including esophagitis and cancer, were found in similar proportions in both groups. These findings support noninvasive approaches to managing dyspepsia in the community, with EGD reserved for those at high risk of malignancy. © 2023 AGA Institute
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