A Consecutive Four-Component Synthesis of Polysubstituted Thiophenes in Aqueous Medium

A Consecutive Four-Component Synthesis of Polysubstituted Thiophenes in Aqueous Medium Publisher

Adib M¹ ; Rajaidaryasarei S¹ ; Pashazadeh R¹ ; Jahani M¹ ; Yazzaf R¹ ; Amanlou M²

Show Affiliations

1. School of Chemistry, College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran
2. Pharmaceutical Sciences Research Center and Department of Medicinal Chemistry, Tehran University of Medical Sciences, Tehran, Iran

Source: European Journal of Organic Chemistry Published:2018

Abstract

An efficient and straightforward four-component synthesis of mono-, bi- and tricyclic thiophenes from C–C + C + C + S atom fragments from 1,3-dicarbonyl compounds, aldehydes, activated methylene halides and elemental sulfur in aqueous medium is described. Arylidene-1,3-dicarbonyls, N-phenacylpyridinium bromides/N-(p-nitrobenzyl)pyridinium chloride, pyridinium ylides and 2,3-dihydrofurans are believed to be the key intermediates of these consecutive transformations. This synthetic strategy provides a potential route to the construction of a library of highly substituted thiophenes with a large substrate scope in good-to-excellent yields. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Experts (# of related papers)

Massoud Amanlou (1)

Style	Citing Format
MLA	Adib M, et al.. "A Consecutive Four-Component Synthesis of Polysubstituted Thiophenes in Aqueous Medium." European Journal of Organic Chemistry, vol. 2018, no. 23, 2018, pp. 3001-3016.
APA	Adib M, Rajaidaryasarei S, Pashazadeh R, Jahani M, Yazzaf R, Amanlou M (2018). A Consecutive Four-Component Synthesis of Polysubstituted Thiophenes in Aqueous Medium. European Journal of Organic Chemistry, 2018(23), 3001-3016.
Chicago	Adib M, Rajaidaryasarei S, Pashazadeh R, Jahani M, Yazzaf R, Amanlou M. "A Consecutive Four-Component Synthesis of Polysubstituted Thiophenes in Aqueous Medium." European Journal of Organic Chemistry 2018, no. 23 (2018): 3001-3016.
Harvard	Adib M et al. (2018) 'A Consecutive Four-Component Synthesis of Polysubstituted Thiophenes in Aqueous Medium', European Journal of Organic Chemistry, 2018(23), pp. 3001-3016.
Vancouver	Adib M, Rajaidaryasarei S, Pashazadeh R, Jahani M, Yazzaf R, Amanlou M. A Consecutive Four-Component Synthesis of Polysubstituted Thiophenes in Aqueous Medium. European Journal of Organic Chemistry. 2018;2018(23):3001-3016.
BibTex	@article{ author = {Adib M and Rajaidaryasarei S and Pashazadeh R and Jahani M and Yazzaf R and Amanlou M}, title = {A Consecutive Four-Component Synthesis of Polysubstituted Thiophenes in Aqueous Medium}, journal = {European Journal of Organic Chemistry}, volume = {2018}, number = {23}, pages = {3001-3016}, year = {2018} }
RIS	TY - JOUR AU - Adib M AU - Rajaidaryasarei S AU - Pashazadeh R AU - Jahani M AU - Yazzaf R AU - Amanlou M TI - A Consecutive Four-Component Synthesis of Polysubstituted Thiophenes in Aqueous Medium JO - European Journal of Organic Chemistry VL - 2018 IS - 23 SP - 3001 EP - 3016 PY - 2018 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract