The Effect of Ginger Supplementation on Some Immunity and Inflammation Intermediate Genes Expression in Patients With Active Rheumatoid Arthritis

The Effect of Ginger Supplementation on Some Immunity and Inflammation Intermediate Genes Expression in Patients With Active Rheumatoid Arthritis Publisher Pubmed

Aryaeian N¹ ; Shahram F² ; Mahmoudi M² ; Tavakoli H³ ; Yousefi B⁴ ; Arablou T¹

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1. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
2. Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Immunology, Semnan University of Medical Sciences, Semnan, Iran

Source: Gene Published:2019

Abstract

Objective: Rheumatoid Arthritis (RA) is an autoimmune disease. The aim of this study was to investigate the effect of ginger supplementation on the expression of some immunity and inflammation intermediate genes in patients who suffer from RA. Methods: In this randomized double-blind placebo-controlled clinical trial, seventy active RA patients were allocated randomly into two groups who either received 1500 mg ginger powder or placebo daily for 12 weeks. Disease activity score and gene expression of NF-κB, PPAR-γ FoxP3, T-bet, GATA-3, and RORγt as immunity and inflammation intermediate factors were measured using quantitative real-time PCR before and after the intervention. Results: After the intervention, FoxP3 genes expression increased significantly within ginger group and between the two groups (P-value = 0.02). Besides, T-bet and RORγt genes expression decreased significantly between the two groups (P-value < 0.05). In ginger group, PPAR-γ genes expression increased significantly (P-value = 0.047) but the difference between the two groups wasn't statistically significant (P-value = 0.12). The reduction in disease activity score was statistically significant within ginger group and between the two groups after the intervention. Conclusion: It seems that ginger can improve RA by decreasing disease manifestations via increasing FoxP3 genes expression and by decreasing RORγt and T-bet genes expression. © 2019

Style	Citing Format
MLA	Aryaeian N, et al.. "The Effect of Ginger Supplementation on Some Immunity and Inflammation Intermediate Genes Expression in Patients With Active Rheumatoid Arthritis." Gene, vol. 698, no. , 2019, pp. 179-185.
APA	Aryaeian N, Shahram F, Mahmoudi M, Tavakoli H, Yousefi B, Arablou T (2019). The Effect of Ginger Supplementation on Some Immunity and Inflammation Intermediate Genes Expression in Patients With Active Rheumatoid Arthritis. Gene, 698(), 179-185.
Chicago	Aryaeian N, Shahram F, Mahmoudi M, Tavakoli H, Yousefi B, Arablou T. "The Effect of Ginger Supplementation on Some Immunity and Inflammation Intermediate Genes Expression in Patients With Active Rheumatoid Arthritis." Gene 698, no. (2019): 179-185.
Harvard	Aryaeian N et al. (2019) 'The Effect of Ginger Supplementation on Some Immunity and Inflammation Intermediate Genes Expression in Patients With Active Rheumatoid Arthritis', Gene, 698(), pp. 179-185.
Vancouver	Aryaeian N, Shahram F, Mahmoudi M, Tavakoli H, Yousefi B, Arablou T. The Effect of Ginger Supplementation on Some Immunity and Inflammation Intermediate Genes Expression in Patients With Active Rheumatoid Arthritis. Gene. 2019;698():179-185.
BibTex	@article{ author = {Aryaeian N and Shahram F and Mahmoudi M and Tavakoli H and Yousefi B and Arablou T}, title = {The Effect of Ginger Supplementation on Some Immunity and Inflammation Intermediate Genes Expression in Patients With Active Rheumatoid Arthritis}, journal = {Gene}, volume = {698}, number = {}, pages = {179-185}, year = {2019} }
RIS	TY - JOUR AU - Aryaeian N AU - Shahram F AU - Mahmoudi M AU - Tavakoli H AU - Yousefi B AU - Arablou T TI - The Effect of Ginger Supplementation on Some Immunity and Inflammation Intermediate Genes Expression in Patients With Active Rheumatoid Arthritis JO - Gene VL - 698 IS - SP - 179 EP - 185 PY - 2019 ER -

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