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Evaluating the Effectiveness of Combined Radiotherapy and Hyperthermia for the Treatment Response of Patients With Painful Bony Metastases: A Phase 2 Clinical Trial Publisher Pubmed



Ariyafar T1 ; Mahdavi SR2 ; Geraily G1 ; Fadavi P3 ; Farhood B4 ; Najafi M5 ; Ashouri A6 ; Khalafi L2 ; Shirazi A1
Authors
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Authors Affiliations
  1. 1. Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Physics, School of Medicine, Iran University of Medical Science, Tehran, Iran
  3. 3. Radiation Oncology Department, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran
  5. 5. Department of Radiology and Nuclear Medicine, School of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran
  6. 6. Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Source: Journal of Thermal Biology Published:2019


Abstract

Introduction: Since the survival time of patients with bony metastases has noticeably improved in recent years, these patients are at high risk of complications associated with this metastasis. Hence, the appropriate choice of treatment modality or combination of therapeutic approaches can lead to increasing bone pain relief, improving quality of life, etc. This study is aimed to evaluate the effectiveness of combined radiotherapy and hyperthermia for the treatment response of patients with painful bony metastases. Patients and methods: In a single-arm clinical trial, 23 eligible patients (14 female and 9 male) with the mean age of 67 years old and suffering from bony metastases were enrolled in the study. Two hours after radiotherapy, the patients underwent hyperthermia for 1 h in the supine position. All the patients completed the brief pain inventory (BPI) assessment tool and quality of life questionnaire (QLQ-C30) from the European Organization for Research and Treatment of Cancer (EORTC) at the baseline, end of the treatment and 1, 2 and 3 months thereafter. The response to the treatment was assessed as the zero score (complete response) or two or more than two-point drop of the worst pain within the preceding 24 h (partial response) during the 3-month posttreatment. Results: All the pain intensity and interference scores, except the pain interference with the enjoyment of life score, significantly decreased. A total of 18 out of 23 patients (78%) achieved complete or partial response. The number of patients using pain relief medications decreased from 74% (n=17) at the baseline to 48% (n=11) 3 months later. Moreover, except for nausea and vomiting, appetite loss, diarrhea and financial impact problems, the patients’ quality of life improved significantly in all the functional scales and symptoms within 3 months. Conclusion: This study showed that using hyperthermia in combination with radiotherapy significantly ameliorated bone pain among the patients suffering from cancer with painful bony metastases. © 2019
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