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The Effect of Propolis on 5-Fluorouracil-Induced Cardiac Toxicity in Rats Publisher Pubmed



Barary M1, 2, 3 ; Hosseinzadeh R3 ; Kazemi S4 ; Liang JJ5 ; Mansouri R3 ; Sio TT6 ; Hosseini M7 ; Moghadamnia AA4
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Virtual School of Medical Education and Management, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Student Research Committee, Babol University of Medical Sciences, Babol, Iran
  4. 4. Cellular and Molecular Biology Research Center, Health Research Center, Babol University of Medical Sciences, Babol, Iran
  5. 5. Division of Cardiovascular Medicine, Cardiac Arrhythmia Service, University of Michigan, Ann Arbor, MI, United States
  6. 6. Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, United States
  7. 7. Department of Veterinary Parasitology, Babol-Branch, Islamic Azad University, Babol, Iran

Source: Scientific Reports Published:2022


Abstract

5-Fluorouracil (5-FU) is one of the most common chemotherapeutic agents used in treating solid tumors, and the 5-FU-induced cardiotoxicity is the second cause of cardiotoxicity induced by chemotherapeutic drugs. Propolis (Pro) has vigorous anti-inflammatory activity. Its cardio-protective characteristic against doxorubicin-induced cardiotoxicity was previously proven. The current study aimed to appraise the effect of Pro on 5-FU-induced cardiotoxicity in rats. Twenty-four male Wistar rats were divided into four groups: Control, 5-FU, 5-FU + Pro 250 mg/kg, and 5-FU + Colchicine (CLC) 5 mg/kg. Different hematological, serological, biochemical, histopathological, and molecular assays were performed to assess the study’s aim. Moreover, a rat myocardium (H9C2(2–1)) cell line was also used to assess this protective effect in-vitro. 5-FU resulted in significant cardiotoxicity represented by an increase in malondialdehyde (MDA) levels, cyclooxygenase-2 (COX-2) and tumor necrosis factor-α (TNF-α) expression, cardiac enzyme levels, and histopathological degenerations. 5-FU treatment also decreased bodyweight, total anti-oxidant capacity (TAC), catalase (CAT) levels, blood cell counts, and hemoglobin (Hb) levels. In addition, 5-FU disrupted ECG parameters, including increased elevation in the ST-segment and increased QRS complex and QTc duration. Treating with Pro reduced oxidative stress, cardiac enzymes, histopathological degenerations, and COX-2 expression in cardiac tissue alleviated ECG disturbances and increased the number of blood cells and TAC levels. Moreover, 5-FU-induced bodyweight loss was ameliorated after treatment with Pro. Our results demonstrated that treatment with Pro significantly improved cardiotoxicity induced by 5-FU in rats. © 2022, The Author(s).
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