Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effect of Topical Honey on Mandibular Bone Defect Healing in Rats Publisher Pubmed



Hajizadeh F1 ; Derakhshan B2 ; Peimani A3 ; Abbasi Z4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Periodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Oral and Maxillofacial Surgery, International Campus School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Oral and Maxillofacial Surgery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  4. 4. Department of Otolaryngology-Head and Neck Surgery, Hamedan University of Medical Sciences, Hamedan, Iran

Source: Journal of Contemporary Dental Practice Published:2018


Abstract

Aim: In medicine, honey is known for its various biological or pharmacological effects, from wound dressing to anticancerogenic and from anti-inflammatory to antibacterial activities. The aim of the current study was to evaluate the effect of honey on healing of mandibular bone defects in a rat model. Materials and methods: This animal study was performed on 24 wild-type Wistar rats. Following shaving, disinfection, and extraoral incision, a 2 × 2 mm defect was created at mandibular angle. In the experimental group, the defect was filled with sterile honey, while it was left unfilled in the control group. The rats were sacrificed after 2 and 4 weeks and defects were assessed histologically. The results were compared using Mann-Whitney U-test (α = 0.05). Results: After 2 weeks, five samples of the experimental group were in mineralization phase, while all samples of the control group were in the vascularization phase (p = 0.015). After 4 weeks, the defects were filled in four samples of the experimental group, while all samples of the control group were in the mineralization stage (p = 0.002). Histomorphometric assessment revealed that the mean new bone formation in the experimental group was significantly more than the control group, both after 2 and 4 weeks (p = 0.041). Conclusion: The results showed that honey could accentuate bone healing of mandibular small defects in rats. © 2018 The Journal of Contemporary Dental Practice.