Synthesis and Labeling of P-Nh2-Bn-Dtpa-(Dabcyl-Lys6,Phe7)-Phbsp With 99Mtc As a Radiopeptide Scintigraphic Agent to Detect Cardiac Ischemia

Synthesis and Labeling of P-Nh2-Bn-Dtpa-(Dabcyl-Lys6,Phe7)-Phbsp With 99Mtc As a Radiopeptide Scintigraphic Agent to Detect Cardiac Ischemia Publisher

Mohtavinejad N¹ ; Bitarafanrajabi A² ; Shafiee Ardestani M¹ ; Darbandiazar A³ ; Khalaj A⁴ ; Ghodrati A⁴ ; Asadi M⁴ ; Amanlou M⁴

Show Affiliations

1. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, 16 Azar Ave., Tehran, Iran
2. Department of Nuclear Medicine, Rajaie Cardiovascular Medical and Research Center, University of Medical Sciences, Tehran, Iran
3. Rajaie Cardiovascular Research Center, Iran University of Medical Sciences, Tehran, Iran
4. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Radioanalytical and Nuclear Chemistry Published:2020

Abstract

Myocardial ischemia and infarction represent a major health burden worldwide, but their immediate diagnosis can reduce mortality and healthcare costs. Pyroglutamate helix B surface peptide (pHBSP) derived from erythropoietin have shown tissue-protective effects in the ischemic situation by binding to erythropoietin receptor–Beta common receptors)EPOR–βcR(. This research aimed to synthesize and biologically evaluate p-NH2-Bn-DTPA-(Lys-Dabcyl6,Phe7)-pHBSP for cardiac ischemia imaging. Radiolabeling yielded more than 97%, and radiolabeled peptide showed significant binding affinity to H9c2 hypoxic cells (p < 0.001). A considerable accumulation of 99mTc-p-NH2-Bn-DTPA-(Lys-Dabcyl6,Phe7)-pHBSP was detected in the ischemic region by biodistribution study and SPECT/CT scintigraphy (3.84 ID/g% at 30 min). © 2020, Akademiai Kiado, Budapest, Hungary.

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Style	Citing Format
MLA	Mohtavinejad N, et al.. "Synthesis and Labeling of P-Nh2-Bn-Dtpa-(Dabcyl-Lys6,Phe7)-Phbsp With 99Mtc As a Radiopeptide Scintigraphic Agent to Detect Cardiac Ischemia." Journal of Radioanalytical and Nuclear Chemistry, vol. 324, no. 2, 2020, pp. 635-646.
APA	Mohtavinejad N, Bitarafanrajabi A, Shafiee Ardestani M, Darbandiazar A, Khalaj A, Ghodrati A, Asadi M, Amanlou M (2020). Synthesis and Labeling of P-Nh2-Bn-Dtpa-(Dabcyl-Lys6,Phe7)-Phbsp With 99Mtc As a Radiopeptide Scintigraphic Agent to Detect Cardiac Ischemia. Journal of Radioanalytical and Nuclear Chemistry, 324(2), 635-646.
Chicago	Mohtavinejad N, Bitarafanrajabi A, Shafiee Ardestani M, Darbandiazar A, Khalaj A, Ghodrati A, Asadi M, Amanlou M. "Synthesis and Labeling of P-Nh2-Bn-Dtpa-(Dabcyl-Lys6,Phe7)-Phbsp With 99Mtc As a Radiopeptide Scintigraphic Agent to Detect Cardiac Ischemia." Journal of Radioanalytical and Nuclear Chemistry 324, no. 2 (2020): 635-646.
Harvard	Mohtavinejad N et al. (2020) 'Synthesis and Labeling of P-Nh2-Bn-Dtpa-(Dabcyl-Lys6,Phe7)-Phbsp With 99Mtc As a Radiopeptide Scintigraphic Agent to Detect Cardiac Ischemia', Journal of Radioanalytical and Nuclear Chemistry, 324(2), pp. 635-646.
Vancouver	Mohtavinejad N, Bitarafanrajabi A, Shafiee Ardestani M, Darbandiazar A, Khalaj A, Ghodrati A, et al.. Synthesis and Labeling of P-Nh2-Bn-Dtpa-(Dabcyl-Lys6,Phe7)-Phbsp With 99Mtc As a Radiopeptide Scintigraphic Agent to Detect Cardiac Ischemia. Journal of Radioanalytical and Nuclear Chemistry. 2020;324(2):635-646.
BibTex	@article{ author = {Mohtavinejad N and Bitarafanrajabi A and Shafiee Ardestani M and Darbandiazar A and Khalaj A and Ghodrati A and Asadi M and Amanlou M}, title = {Synthesis and Labeling of P-Nh2-Bn-Dtpa-(Dabcyl-Lys6,Phe7)-Phbsp With 99Mtc As a Radiopeptide Scintigraphic Agent to Detect Cardiac Ischemia}, journal = {Journal of Radioanalytical and Nuclear Chemistry}, volume = {324}, number = {2}, pages = {635-646}, year = {2020} }
RIS	TY - JOUR AU - Mohtavinejad N AU - Bitarafanrajabi A AU - Shafiee Ardestani M AU - Darbandiazar A AU - Khalaj A AU - Ghodrati A AU - Asadi M AU - Amanlou M TI - Synthesis and Labeling of P-Nh2-Bn-Dtpa-(Dabcyl-Lys6,Phe7)-Phbsp With 99Mtc As a Radiopeptide Scintigraphic Agent to Detect Cardiac Ischemia JO - Journal of Radioanalytical and Nuclear Chemistry VL - 324 IS - 2 SP - 635 EP - 646 PY - 2020 ER -

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