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Association of Malnutrition-Inflammation Score, Dialysis-Malnutrition Score and Serum Albumin With Novel Risk Factors for Cardiovascular Diseases in Hemodialysis Patients Publisher Pubmed



Ashabi A1 ; Tabibi H2 ; Hedayati M3 ; Mahdavimazdeh M4 ; Nozaryheshmati B5
Authors
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Authors Affiliations
  1. 1. Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, 46, West Arghavan St., Farahzadi Blvd., Shahrak Qods, Tehran, Iran
  3. 3. Cellular and Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Nephrology, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Iranian Tissue Bank, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Renal Failure Published:2015


Abstract

Background: This study was designed to investigate the associations between malnutrition-inflammation score (MIS), dialysis-malnutrition score (DMS) and serum albumin with novel risk factors for cardiovascular diseases (CVD) in hemodialysis (HD) patients. Methods: In this cross-sectional study, 291 HD patients were randomly selected from among 2302 adult HD patients in Tehran HD centers. The MIS and DMS were determined during one of the dialysis sessions in these patients. In addition, 4mL blood was obtained before dialysis and analyzed for serum albumin and novel risk factors for CVD, including C-reactive protein (CRP), soluble intercellular adhesion molecule type 1 (sICAM-1), soluble vascular cell adhesion molecule type 1 (sVCAM-1), sE-selectin, malondialdehyde (MDA), nitric oxide (NO), endothelin-1 and lipoprotein (a) [Lp (a)]. Results: MIS and DMS were significantly positively correlated with serum CRP (p<0.01) and sICAM-1 (p<0.01), whereas serum albumin concentration was significantly negatively correlated with serum CRP (p<0.01) and sICAM-1 (p<0.01). There were no significant correlations between MIS, DMS and serum albumin with serum concentrations of sVCAM-1, sE-selectin, MDA, NO, endothelin-1 and Lp (a). Conclusion: This study indicates that protein-energy wasting indicators in HD patients are associated with serum CRP and sICAM-1, as two CVD risk factors. © 2015 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted.
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