Comparative Transcriptional Analysis for Toll-Like Receptors, Inflammatory Cytokines, and Apoptotic Genes in Response to Different Cytolethal-Encoding and Noncoding Isolates of Salmonella Enterica and Campylobacter Jejuni From Food and Human Stool

Comparative Transcriptional Analysis for Toll-Like Receptors, Inflammatory Cytokines, and Apoptotic Genes in Response to Different Cytolethal-Encoding and Noncoding Isolates of Salmonella Enterica and Campylobacter Jejuni From Food and Human Stool Publisher Pubmed

Ganji L^{1, 2, 3} ; Alebouyeh M^{2, 4} ; Shirazi MH¹ ; Zali MR⁵

Show Affiliations

1. Department of Pathobiology, School of Public Health, University of Medical Sciences, Tehran, Iran
2. Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Research Center of Health Reference Laboratory, Ministry of Health and Medical Education, Tehran, Iran
4. Pediatric Infections Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Science, Tehran, Iran

Source: Microbial Pathogenesis Published:2019

Abstract

Diversity of Campylobacter and Salmonella strains in interaction with epithelial cells may explain distinct modes of the pathogenesis, varying from mild watery to severe inflammatory diarrhea. We analyzed impact of this diversity, in relation to carriage and expression of cytholethal distending toxin B (cdtB), on alteration of IL-8, TNF-α, TLR2, TLR4, TLR5, CASP3 mRNA and cytokine levels in HT-29 cell line. A diversity was observed for induction of genes among different strains. Great diversity in IL-8 induction was detected between cdtB+ and cdtB− strains. Early analysis showed down-regulation of TNF-α, mostly among cdtB+ strains. Any increase or decrease in expression of TLR2 in the cdtB− C. jejuni strains was orderly correlated with increase or decrease of TLR4 and TNF-α. Up-regulation of CASP3 was followed by upregulation of TLR2, -4 and/or TNF-α, regardless to the cdtB status. In conclusion, induction of inflammatory response could mediate by distinct C. jejuni and S. enterica strains by several ways. © 2019 Elsevier Ltd

Style	Citing Format
MLA	Ganji L, et al.. "Comparative Transcriptional Analysis for Toll-Like Receptors, Inflammatory Cytokines, and Apoptotic Genes in Response to Different Cytolethal-Encoding and Noncoding Isolates of Salmonella Enterica and Campylobacter Jejuni From Food and Human Stool." Microbial Pathogenesis, vol. 133, no. , 2019, pp. -.
APA	Ganji L, Alebouyeh M, Shirazi MH, Zali MR (2019). Comparative Transcriptional Analysis for Toll-Like Receptors, Inflammatory Cytokines, and Apoptotic Genes in Response to Different Cytolethal-Encoding and Noncoding Isolates of Salmonella Enterica and Campylobacter Jejuni From Food and Human Stool. Microbial Pathogenesis, 133(), -.
Chicago	Ganji L, Alebouyeh M, Shirazi MH, Zali MR. "Comparative Transcriptional Analysis for Toll-Like Receptors, Inflammatory Cytokines, and Apoptotic Genes in Response to Different Cytolethal-Encoding and Noncoding Isolates of Salmonella Enterica and Campylobacter Jejuni From Food and Human Stool." Microbial Pathogenesis 133, no. (2019): -.
Harvard	Ganji L et al. (2019) 'Comparative Transcriptional Analysis for Toll-Like Receptors, Inflammatory Cytokines, and Apoptotic Genes in Response to Different Cytolethal-Encoding and Noncoding Isolates of Salmonella Enterica and Campylobacter Jejuni From Food and Human Stool', Microbial Pathogenesis, 133(), pp. -.
Vancouver	Ganji L, Alebouyeh M, Shirazi MH, Zali MR. Comparative Transcriptional Analysis for Toll-Like Receptors, Inflammatory Cytokines, and Apoptotic Genes in Response to Different Cytolethal-Encoding and Noncoding Isolates of Salmonella Enterica and Campylobacter Jejuni From Food and Human Stool. Microbial Pathogenesis. 2019;133():-.
BibTex	@article{ author = {Ganji L and Alebouyeh M and Shirazi MH and Zali MR}, title = {Comparative Transcriptional Analysis for Toll-Like Receptors, Inflammatory Cytokines, and Apoptotic Genes in Response to Different Cytolethal-Encoding and Noncoding Isolates of Salmonella Enterica and Campylobacter Jejuni From Food and Human Stool}, journal = {Microbial Pathogenesis}, volume = {133}, number = {}, pages = {-}, year = {2019} }
RIS	TY - JOUR AU - Ganji L AU - Alebouyeh M AU - Shirazi MH AU - Zali MR TI - Comparative Transcriptional Analysis for Toll-Like Receptors, Inflammatory Cytokines, and Apoptotic Genes in Response to Different Cytolethal-Encoding and Noncoding Isolates of Salmonella Enterica and Campylobacter Jejuni From Food and Human Stool JO - Microbial Pathogenesis VL - 133 IS - SP - EP - PY - 2019 ER -

Style

Citing Format

MLA

Ganji L, et al.. "Comparative Transcriptional Analysis for Toll-Like Receptors, Inflammatory Cytokines, and Apoptotic Genes in Response to Different Cytolethal-Encoding and Noncoding Isolates of Salmonella Enterica and Campylobacter Jejuni From Food and Human Stool." Microbial Pathogenesis, vol. 133, no. , 2019, pp. -.

APA

Ganji L, Alebouyeh M, Shirazi MH, Zali MR (2019). Comparative Transcriptional Analysis for Toll-Like Receptors, Inflammatory Cytokines, and Apoptotic Genes in Response to Different Cytolethal-Encoding and Noncoding Isolates of Salmonella Enterica and Campylobacter Jejuni From Food and Human Stool. Microbial Pathogenesis, 133(), -.

Chicago

Ganji L, Alebouyeh M, Shirazi MH, Zali MR. "Comparative Transcriptional Analysis for Toll-Like Receptors, Inflammatory Cytokines, and Apoptotic Genes in Response to Different Cytolethal-Encoding and Noncoding Isolates of Salmonella Enterica and Campylobacter Jejuni From Food and Human Stool." Microbial Pathogenesis 133, no. (2019): -.

Harvard

Ganji L et al. (2019) 'Comparative Transcriptional Analysis for Toll-Like Receptors, Inflammatory Cytokines, and Apoptotic Genes in Response to Different Cytolethal-Encoding and Noncoding Isolates of Salmonella Enterica and Campylobacter Jejuni From Food and Human Stool', Microbial Pathogenesis, 133(), pp. -.

Vancouver

Ganji L, Alebouyeh M, Shirazi MH, Zali MR. Comparative Transcriptional Analysis for Toll-Like Receptors, Inflammatory Cytokines, and Apoptotic Genes in Response to Different Cytolethal-Encoding and Noncoding Isolates of Salmonella Enterica and Campylobacter Jejuni From Food and Human Stool. Microbial Pathogenesis. 2019;133():-.

BibTex

@article{ author = {Ganji L and Alebouyeh M and Shirazi MH and Zali MR}, title = {Comparative Transcriptional Analysis for Toll-Like Receptors, Inflammatory Cytokines, and Apoptotic Genes in Response to Different Cytolethal-Encoding and Noncoding Isolates of Salmonella Enterica and Campylobacter Jejuni From Food and Human Stool}, journal = {Microbial Pathogenesis}, volume = {133}, number = {}, pages = {-}, year = {2019} }

RIS

TY - JOUR
AU - Ganji L
AU - Alebouyeh M
AU - Shirazi MH
AU - Zali MR
TI - Comparative Transcriptional Analysis for Toll-Like Receptors, Inflammatory Cytokines, and Apoptotic Genes in Response to Different Cytolethal-Encoding and Noncoding Isolates of Salmonella Enterica and Campylobacter Jejuni From Food and Human Stool
JO - Microbial Pathogenesis
VL - 133
IS -
SP -
EP -
PY - 2019
ER -

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