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The Effect of Uni-Hemispheric Dual-Site Anodal Tdcs on Brain Metabolic Changes in Stroke Patients: A Randomized Clinical Trial Publisher



Azarnia S1 ; Ezzati K2 ; Saberi A2 ; Naghdi S3 ; Abdollahi I4 ; Jaberzadeh S5
Authors
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Authors Affiliations
  1. 1. Department of Physiotherapy, Iranian Research Centre on Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, 19857-13834, Iran
  2. 2. Neuroscience Research Centre, Poorsina Hospital, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, 41937-13111, Iran
  3. 3. Department of Physiotherapy, Faculty of Rehabilitation, Tehran University of Medical Sciences, Tehran, 65111-11489, Iran
  4. 4. Department of Physiotherapy, Faculty of Rehabilitation, University of Social Welfare and Rehabilitation Sciences, Tehran, 19857-13834, Iran
  5. 5. Department of Physiotherapy, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, 3800, VIC, Australia

Source: Brain Sciences Published:2023


Abstract

Uni-hemispheric concurrent dual-site anodal transcranial direct current stimulation (UHCDS a-tDCS) of the primary motor cortex (M1) and the dorsolateral prefrontal cortex (DLPFC) may enhance the efficacy of a-tDCS after stroke. However, the cellular and molecular mechanisms underlying its beneficial effects have not been defined. We aimed to investigate the effect of a-tDCSM1-DLPFC on brain metabolite concentrations (N-acetyl aspartate (NAA), choline (Cho)) in stroke patients using magnetic resonance spectroscopy (MRS). In this double-blind, sham-controlled, randomized clinical trial (RCT), 18 patients with a first chronic stroke in the territory of the middle cerebral artery trunk were recruited. Patients were allocated to one of the following two groups: (1) Experimental 1, who received five consecutive sessions of a-tDCSM1-DLPFC M1 (active)-DLPFC (active). (2) Experimental 2, who received five consecutive sessions of a-tDCSM1-DLPFC M1 (active)-DLPFC (sham). MRS assessments were performed before and 24 h after the last intervention. Results showed that after five sessions of a-tDCSM1-DLPFC, there were no significant changes in NAA and Cho levels between groups (Cohen’s d = 1.4, Cohen’s d = 0.93). Thus, dual site a-tDCSM1-DLPFC did not affect brain metabolites compared to single site a-tDCS M1. © 2023 by the authors.
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