Diagnostic Performance of the #Enzian Classification Via Ultrasound Compared to Laparoscopic Findings in Endometriosis: A Retrospective Cohort Study Publisher



Asgari Z ; Boostan A ; Hosseini R ; Ghavami B ; Khakifirooz B ; Bayani L ; Mardani R ; Hajialigol A ; Rashidian P
Source: Journal of the Turkish German Gynecology Association Published:2025

Abstract

Objective: To assess the diagnostic performance of the ultrasound-based #Enzian classification in comparison with laparoscopic surgical findings in patients with endometriosis. Material and Methods: This retrospective cohort study included patients who underwent laparoscopic excisional surgery for endometriosis between September 2023 and October 2024. Preoperative transvaginal ultrasound assessments were performed using the International Deep Endometriosis Analysis protocol, with findings recorded according to the updated #Enzian classification. Diagnostic performance was evaluated through sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy. Statistical analyses were conducted using SPSS version 26.0.0.0, with statistical significance set at p<0.05. Results: The study included 66 patients. The #Enzian classification demonstrated the highest diagnostic accuracy in compartments FA and FB (98.82% and 98.59%, respectively), both with perfect sensitivity and minimal false positives. The left ovary (O left) also showed strong performance (92.87% accuracy). In contrast, compartment A had low sensitivity (12.12%) despite a low false-positive rate. Compartments B left and C exhibited good accuracy (86.82% and 91.88%), with minimal false positives and moderate sensitivity. Variable results were observed in compartments O right and T. Although sensitivity was incomplete for FU, FI, and FO, specificity remained high across these subgroups. Conclusion: The #Enzian ultrasound classification provides a reliable diagnostic framework, demonstrating high accuracy across multiple compartments. It is recommended that future studies include larger sample sizes and longitudinal design to further validate these findings. [J Turk Ger Gynecol Assoc. 2025; 26(4): 276-83]. © 2025 The Author. Published by Galenos Publishing House on behalf of Turkish-German Gynecological Association.