Drug-Loaded Polymeric Films As a Promising Tool for the Treatment of Periodontitis Publisher



Ghavamilahiji M^{1, 2} ; Shafiei F^{1, 2} ; Najafi F³ ; Erfan M⁴ Show Affiliations
Source: Journal of Drug Delivery Science and Technology Published:2019

Abstract

This study addresses the fabrication and characterization of poly-caprolactone/alginic acid based drug-containing polymeric films. Two basic drugs used in the treatment of periodontal diseases (metronidazole and doxycycline) were investigated. The polymeric films were characterized by DSC, XRD, FTIR, and SEM. A decrease in the mechanical stability, such as tensile strength of the drug-loaded composite film, was observed with increasing drug content in comparison to drug-free composite films. Also, drug incorporation into the polymer caused an increase in the water absorption capacity and accelerated the films’ weight loss. This study demonstrated the potential for the application of drug-loaded periodontal films as a promising control release system that can be designed to fit in the form of a ring around the teeth and removed after a week. The application in the form of a disposable toothpick allows the dentist to access untouched areas of deep pockets and fistulas after mechanical debridement. © 2019 Elsevier B.V.