Conditioning Intensity in Middle-Aged Patients With Aml in First Cr: No Advantage for Myeloablative Regimens Irrespective of the Risk Group-An Observational Analysis by the Acute Leukemia Working Party of the Ebmt

Conditioning Intensity in Middle-Aged Patients With Aml in First Cr: No Advantage for Myeloablative Regimens Irrespective of the Risk Group-An Observational Analysis by the Acute Leukemia Working Party of the Ebmt Publisher Pubmed

Passweg JR¹ ; Labopin M² ; Cornelissen J³ ; Volin L⁴ ; Socie G⁵ ; Huynh A⁶ ; Tabrizi R⁷ ; Wu D⁸ ; Craddock C⁹ ; Schaap N¹⁰ ; Kuball J¹¹ ; Chevallier P¹² ; Cahn JY¹³ ; Blaise D¹⁴ Show All Authors

Passweg JR¹
Labopin M²
Cornelissen J³
Volin L⁴
Socie G⁵
Huynh A⁶
Tabrizi R⁷
Wu D⁸
Craddock C⁹
Schaap N¹⁰
Kuball J¹¹
Chevallier P¹²
Cahn JY¹³
Blaise D¹⁴
Ghavamzadeh A¹⁵
Bilger K¹⁶
Ciceri F¹⁷
Schmid C¹⁸
Giebel S¹⁹
Nagler A²⁰
Mohty M²¹

Show Affiliations

1. Division of Hematology, University Hospital Basel, Basel, CH-4031, Switzerland
2. EBMT Paris Study Office, Paris, France
3. Erasmus MC-Daniel den Hoed Cancer Centre, Rotterdam, Netherlands
4. Stem Cell Transplantation Unit, Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland
5. Division of Hematology, Hospital St Louis and University Paris, Paris, France
6. CHU Department Hematologie, Hopital de Purpan, Toulouse, France
7. CHU Bordeaux, Hopital Haut-leveque, Pessac, France
8. Department of Hematology, First Affiliated Hospital, Soochow University, Suzhou, China
9. Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, United Kingdom
10. Department of Hematology, Nijmegen Medical Centre, Radboud University, Nijmegen, Netherlands
11. Department of Hematology, University Medical Center Utrecht, Utrecht, Netherlands
12. Department D'Hematologie, CHU Nantes, Nantes, France
13. Clinique Universitaire d'Hematologie CHU Grenoble, Grenoble, France
14. Departement D'Onco-Hematologie, Institut Paoli Calmettes, Marseille, France
15. Hematology-Oncology and BMT Research, Shariati Hospital, Teheran, Iran
16. CHU Hautepierre, Service d'Onco Hematologie, Strasbourg, France
17. Ospedale San Raffaele, Milan, Italy
18. Medizinische Klinik II, Klinikum Augsburg, Augsburg, Germany
19. Department of Bone Marrow Transplantation and Hematology-Oncology, Maria Sklodowska-Curie Memorial Cancer Center, Gliwice, Poland
20. Hematology Division, Chaim Sheba Medical Center, Tel-Hashomer, Israel
21. Department of Hematology, Hospital Saint Antoine, Paris, France

Source: Bone Marrow Transplantation Published:2015

Abstract

In recipients of allogeneic hematopoietic stem cell transplantation with AML in CR1, reduced intensity (RIC) conditioning regimens are usually given to older patients and myeloablative regimens (MAC) to younger patients. We analyzed whether in middle-aged patients aged 40-60 years, MAC was superior to RIC in cytogenetically higher risk AML. Among 2974 patients, 1638 had MAC and 1336 RIC transplants. Cytogenetics were high risk in 508, intermediate risk in 2297 and low risk in 169. Overall survival (OS) was higher in patients with RIC with low-risk cytogenetics but not in the intermediate- or poor-risk AML. Relapse incidence was lower with MAC in poor- and intermediate-risk AML. Nonrelapse mortality (NRM) was higher in MAC in all cytogenetic risk groups. Multivariate analysis confirmed a significant leukemia-free survival and OS advantage for RIC in low risk but no advantage of MAC in intermediate- and poor-risk leukemia. In patients aged 40-60 years, MAC has no advantage over RIC. We confirm lower relapse but higher NRM risks with MAC. MAC is not superior in patients with higher risk cytogenetics, but is inferior to RIC in the small cohort of AML patients with low-risk cytogenetics. © 2015 Macmillan Publishers Limited.

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Style	Citing Format
MLA	Passweg JR, et al.. "Conditioning Intensity in Middle-Aged Patients With Aml in First Cr: No Advantage for Myeloablative Regimens Irrespective of the Risk Group-An Observational Analysis by the Acute Leukemia Working Party of the Ebmt." Bone Marrow Transplantation, vol. 50, no. 8, 2015, pp. 1063-1068.
APA	Passweg JR, Labopin M, Cornelissen J, Volin L, Socie G, Huynh A, Tabrizi R, Wu D, Craddock C, Schaap N, Kuball J, Chevallier P, Cahn JY, Blaise D, Ghavamzadeh A, Bilger K, Ciceri F, Schmid C, Giebel S, ... Mohty M (2015). Conditioning Intensity in Middle-Aged Patients With Aml in First Cr: No Advantage for Myeloablative Regimens Irrespective of the Risk Group-An Observational Analysis by the Acute Leukemia Working Party of the Ebmt. Bone Marrow Transplantation, 50(8), 1063-1068.
Chicago	Passweg JR, Labopin M, Cornelissen J, Volin L, Socie G, Huynh A, Tabrizi R, et al.. "Conditioning Intensity in Middle-Aged Patients With Aml in First Cr: No Advantage for Myeloablative Regimens Irrespective of the Risk Group-An Observational Analysis by the Acute Leukemia Working Party of the Ebmt." Bone Marrow Transplantation 50, no. 8 (2015): 1063-1068.
Harvard	Passweg JR et al. (2015) 'Conditioning Intensity in Middle-Aged Patients With Aml in First Cr: No Advantage for Myeloablative Regimens Irrespective of the Risk Group-An Observational Analysis by the Acute Leukemia Working Party of the Ebmt', Bone Marrow Transplantation, 50(8), pp. 1063-1068.
Vancouver	Passweg JR, Labopin M, Cornelissen J, Volin L, Socie G, Huynh A, et al.. Conditioning Intensity in Middle-Aged Patients With Aml in First Cr: No Advantage for Myeloablative Regimens Irrespective of the Risk Group-An Observational Analysis by the Acute Leukemia Working Party of the Ebmt. Bone Marrow Transplantation. 2015;50(8):1063-1068.
BibTex	@article{ author = {Passweg JR and Labopin M and Cornelissen J and Volin L and Socie G and Huynh A and Tabrizi R and Wu D and Craddock C and Schaap N and Kuball J and Chevallier P and Cahn JY and Blaise D and Ghavamzadeh A and Bilger K and Ciceri F and Schmid C and Giebel S and Nagler A and Mohty M}, title = {Conditioning Intensity in Middle-Aged Patients With Aml in First Cr: No Advantage for Myeloablative Regimens Irrespective of the Risk Group-An Observational Analysis by the Acute Leukemia Working Party of the Ebmt}, journal = {Bone Marrow Transplantation}, volume = {50}, number = {8}, pages = {1063-1068}, year = {2015} }
RIS	TY - JOUR AU - Passweg JR AU - Labopin M AU - Cornelissen J AU - Volin L AU - Socie G AU - Huynh A AU - Tabrizi R AU - Wu D AU - Craddock C AU - Schaap N AU - Kuball J AU - Chevallier P AU - Cahn JY AU - Blaise D AU - Ghavamzadeh A AU - Bilger K AU - Ciceri F AU - Schmid C AU - Giebel S AU - Nagler A AU - Mohty M TI - Conditioning Intensity in Middle-Aged Patients With Aml in First Cr: No Advantage for Myeloablative Regimens Irrespective of the Risk Group-An Observational Analysis by the Acute Leukemia Working Party of the Ebmt JO - Bone Marrow Transplantation VL - 50 IS - 8 SP - 1063 EP - 1068 PY - 2015 ER -

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