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Synthesis of the Olanzapine Labeled by Carbon-14 Publisher Pubmed



Saadatjoo N1 ; Javaheri M1, 2 ; Saemian N2 ; Amini M3
Authors
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Authors Affiliations
  1. 1. Department of Organic Chemistry, Faculty of Chemistry, Semnan University, PO Box: 35131-19111, Semnan, Iran
  2. 2. Applied Radiations Research School, Nuclear Science & Technology Research Institute, Karegare Shomali Street, P.O. Box 11365-3486, Tehran, Iran
  3. 3. Department of Medicinal Chemistry, Faculty of Pharmacy and Drug Design & Development Research Center, Tehran University of Medical Sciences, Tehran, 14176, Iran

Source: Journal of Labelled Compounds and Radiopharmaceuticals Published:2016


Abstract

Olanzapine is one of the most widely used antipsychotic drugs, which acts as an antagonist for multiple neurotransmitter receptor sites. 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b][1,5] benzodiazepine (Olanzapine) labeled with carbon-14 in the four positions has been synthesized as part of a three-step sequence from 2-amino-5-methylthiophene-3-carbonitrile-[carbonitrile-14C]. Copyright © 2016 John Wiley & Sons, Ltd.