Serum Hypercoagulability States in Coats’ Disease

Serum Hypercoagulability States in Coats’ Disease Publisher

Ghassemi F¹ ; Shields CL² ; Mohebbi M¹ ; Ahmadabadi MN¹ ; Morsali F¹ ; Sabour S^{3, 4}

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1. Ocular Oncology and Retina and Vitreous Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
2. Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, United States
3. Safety Promotion and Injury Prevention Research Centre, Iran
4. Department of Clinical Epidemiology, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Clinical Ophthalmology Published:2017

Abstract

Purpose: The purpose of this study was to investigate the serum hypercoagulability state and common viral and protozoan infections in Coats’ disease versus a normal control group. Materials and methods: In this comparative case series, 22 consecutive patients with Coats’ disease and 19 non-Coats’ patients undergoing lensectomy for congenital, traumatic, or senile cataract between January 2011 and June 2014 were included. Laboratory data for hypercoagulability states and common viral and protozoan infections were investigated. Results: The mean age for the Coats’ group was 14.5 years (median 8 years, range: 2 months to 59 years), and for the control group it was 30.6 years (median 17 years, range: 2–82 years). In patients aged 10 years or younger, anticytomegalovirus immunoglobulin G (IgG) (P≤0.01), homocysteine (P=0.03), and serum beta globulin (P<0.001) were associated with Coats’ disease. In those older than 10 years, higher serum protein S (P=0.04), beta globulin (P=0.05), and gamma globulin (P=0.04) were related to Coats’ diagnosis. After adjusting for sex and age as confounding factors, only beta globulin was found to be associated with Coats’ disease in logistic regression analysis (odds ratio: 1.8, 95% confidence interval: 1.0–3.1, P=0.02). Conclusion: Serum beta globulin levels appear to be elevated in patients with Coats’ disease. © 2017 Ghassemi et al.

Style	Citing Format
MLA	Ghassemi F, et al.. "Serum Hypercoagulability States in Coats’ Disease." Clinical Ophthalmology, vol. 11, no. , 2017, pp. 305-310.
APA	Ghassemi F, Shields CL, Mohebbi M, Ahmadabadi MN, Morsali F, Sabour S (2017). Serum Hypercoagulability States in Coats’ Disease. Clinical Ophthalmology, 11(), 305-310.
Chicago	Ghassemi F, Shields CL, Mohebbi M, Ahmadabadi MN, Morsali F, Sabour S. "Serum Hypercoagulability States in Coats’ Disease." Clinical Ophthalmology 11, no. (2017): 305-310.
Harvard	Ghassemi F et al. (2017) 'Serum Hypercoagulability States in Coats’ Disease', Clinical Ophthalmology, 11(), pp. 305-310.
Vancouver	Ghassemi F, Shields CL, Mohebbi M, Ahmadabadi MN, Morsali F, Sabour S. Serum Hypercoagulability States in Coats’ Disease. Clinical Ophthalmology. 2017;11():305-310.
BibTex	@article{ author = {Ghassemi F and Shields CL and Mohebbi M and Ahmadabadi MN and Morsali F and Sabour S}, title = {Serum Hypercoagulability States in Coats’ Disease}, journal = {Clinical Ophthalmology}, volume = {11}, number = {}, pages = {305-310}, year = {2017} }
RIS	TY - JOUR AU - Ghassemi F AU - Shields CL AU - Mohebbi M AU - Ahmadabadi MN AU - Morsali F AU - Sabour S TI - Serum Hypercoagulability States in Coats’ Disease JO - Clinical Ophthalmology VL - 11 IS - SP - 305 EP - 310 PY - 2017 ER -

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