Nanofibrous Composites Reinforced by Mos2 Nanosheets As a Conductive Scaffold for Cardiac Tissue Engineering

Nanofibrous Composites Reinforced by Mos2 Nanosheets As a Conductive Scaffold for Cardiac Tissue Engineering Publisher

Nazari H^{1, 2} ; Heiranitabasi A^{1, 2} ; Alavijeh MS³ ; Jeshvaghani ZS⁴ ; Esmaeili E^{2, 5} ; Hosseinzadeh S⁶ ; Mohabatpour F⁷ ; Taheri B^{2, 5} ; Tafti SHA¹ ; Soleimani M²

Show Affiliations

1. Research center for advanced technologies in cardiovascular medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Cell Therapy and Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
3. Department of Mechanical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
4. Department of Biotechnology, College of science, University of Tehran, Tehran, Iran
5. Stem Cell Technology Research Center, Tehran, Iran
6. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7. Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada

Source: ChemistrySelect Published:2019

Abstract

Mimicking the structure of extracellular matrix and electrical conductivity of myocardium are required to regenerate the functional cardiac tissue. In this study, Molybdenum disulfide, MoS2, nanosheets were synthesized and incorporated into nylon6 electrospun nanofibers in order to enhance the mechanical properties and electrical conductivity of the scaffolds. Then, the mouse embryonic cardiac cells, mECCs, were seeded on the scaffolds for in vitro studies. The MoS2 nanosheets were studied by scanning electron microscopy (SEM) and Raman spectroscopy. Nylon/MoS2 nanofibers were characterized by SEM, transmission electron microscopy (TEM), water contact angle measurement, electrical conductivity, and tensile test. Furthermore, cytocompatibility of scaffolds was confirmed by 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide, MTT, assay. SEM images showed more elongated morphology for mECCs attached to the nylon/MoS2 scaffold. Also, the Real-Time PCR and immunostaining studies indicated the maturation and upregulation of cardiac functional genes including GATA-4, c-TnT, Nkx 2.5 and α-MHC in the nylon/MoS2 scaffold in comparison to the bare nylon. Therefore, MoS2 reinforced nylon nanofibrous scaffolds can be considered as a suitable candidate in cardiac tissue engineering. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Style	Citing Format
MLA	Nazari H, et al.. "Nanofibrous Composites Reinforced by Mos2 Nanosheets As a Conductive Scaffold for Cardiac Tissue Engineering." ChemistrySelect, vol. 4, no. 39, 2019, pp. 11557-11563.
APA	Nazari H, Heiranitabasi A, Alavijeh MS, Jeshvaghani ZS, Esmaeili E, Hosseinzadeh S, Mohabatpour F, Taheri B, Tafti SHA, Soleimani M (2019). Nanofibrous Composites Reinforced by Mos2 Nanosheets As a Conductive Scaffold for Cardiac Tissue Engineering. ChemistrySelect, 4(39), 11557-11563.
Chicago	Nazari H, Heiranitabasi A, Alavijeh MS, Jeshvaghani ZS, Esmaeili E, Hosseinzadeh S, Mohabatpour F, Taheri B, Tafti SHA, Soleimani M. "Nanofibrous Composites Reinforced by Mos2 Nanosheets As a Conductive Scaffold for Cardiac Tissue Engineering." ChemistrySelect 4, no. 39 (2019): 11557-11563.
Harvard	Nazari H et al. (2019) 'Nanofibrous Composites Reinforced by Mos2 Nanosheets As a Conductive Scaffold for Cardiac Tissue Engineering', ChemistrySelect, 4(39), pp. 11557-11563.
Vancouver	Nazari H, Heiranitabasi A, Alavijeh MS, Jeshvaghani ZS, Esmaeili E, Hosseinzadeh S, et al.. Nanofibrous Composites Reinforced by Mos2 Nanosheets As a Conductive Scaffold for Cardiac Tissue Engineering. ChemistrySelect. 2019;4(39):11557-11563.
BibTex	@article{ author = {Nazari H and Heiranitabasi A and Alavijeh MS and Jeshvaghani ZS and Esmaeili E and Hosseinzadeh S and Mohabatpour F and Taheri B and Tafti SHA and Soleimani M}, title = {Nanofibrous Composites Reinforced by Mos2 Nanosheets As a Conductive Scaffold for Cardiac Tissue Engineering}, journal = {ChemistrySelect}, volume = {4}, number = {39}, pages = {11557-11563}, year = {2019} }
RIS	TY - JOUR AU - Nazari H AU - Heiranitabasi A AU - Alavijeh MS AU - Jeshvaghani ZS AU - Esmaeili E AU - Hosseinzadeh S AU - Mohabatpour F AU - Taheri B AU - Tafti SHA AU - Soleimani M TI - Nanofibrous Composites Reinforced by Mos2 Nanosheets As a Conductive Scaffold for Cardiac Tissue Engineering JO - ChemistrySelect VL - 4 IS - 39 SP - 11557 EP - 11563 PY - 2019 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract