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Data From Quantitative Serum Proteomic Analysis After Laparoscopic Gastric Plication Publisher



Savedoroudi P1, 2 ; Bennike TB2 ; Kastaniegaard K2 ; Talebpour M3 ; Ghassempour A1 ; Stensballe A2
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Authors Affiliations
  1. 1. Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran
  2. 2. Department of Health Science and Technology, Aalborg University, Denmark
  3. 3. Laparoscopic Surgery Ward, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Data in Brief Published:2019


Abstract

Bariatric surgery is an effective treatment for morbid obesity with a sustained weight loss and improvements in metabolic syndrome. We present a label free quantitative shotgun proteomics approach to analyze the serum proteome of obese people who underwent Laparoscopic Gastric Plication (LGP) as a new bariatric surgery. Pre-surgery serum samples of obese individuals were compared with the serum of the same subjects 1–2 months post-surgery (T1) and 4–5 months post-surgery (T2). The data provide a list of 224 quantifiable proteins with at least two unique peptides that were quantifiable in at least 70% of samples. Gene ontology biological processes and molecular functions of differentially regulated proteins between pre- and post-surgery samples were investigated using WebGestalt online tool. In addition, molecular networks of differentially abundant proteins were determined through Ingenuity Pathway Analysis (IPA) software. This report is related to the research article entitled “Serum proteome changes and accelerated reduction of fat mass after Laparoscopic Gastric Plication in morbidly obese patients” (Savedoroudi et al. [1]). Proteomics data have been deposited to the ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) via the PRIDE partner repository through the identifier PXD010528. © 2019 The Author(s)