Diabetes Is Associated With Increased Liver Cancer Incidence and Mortality in Adults: A Report From Asia Cohort Consortium

Diabetes Is Associated With Increased Liver Cancer Incidence and Mortality in Adults: A Report From Asia Cohort Consortium Publisher

Ho NT¹ ; Abe SK² ; Rahman MS^{2, 3} ; Islam R^{2, 4} ; Saito E⁵ ; Gupta PC⁶ ; Pednekar MS⁶ ; Sawada N⁷ ; Tsugane S^{7, 8} ; Tamakoshi A⁹ ; Kimura T⁹ ; Shu XO¹⁰ ; Gao YT¹¹ ; Koh WP^{12, 13} Show All Authors

Ho NT¹
Abe SK²
Rahman MS^{2, 3}
Islam R^{2, 4}
Saito E⁵
Gupta PC⁶
Pednekar MS⁶
Sawada N⁷
Tsugane S^{7, 8}
Tamakoshi A⁹
Kimura T⁹
Shu XO¹⁰
Gao YT¹¹
Koh WP^{12, 13}
Cai H¹⁰
Wen W¹⁰
Sakata R¹⁴
Tsuji I¹⁵
Malekzadeh R¹⁶
Pourshams A¹⁷
Kanemura S¹⁵
Kim J¹⁸
Chen Y¹⁹
Ito H^{20, 21}
Oze I²⁰
Nagata C²²
Wada K²²
Sugawara Y²³
Park SK²⁴
Shin A^{24, 25}
Yuan JM^{26, 27}
Wang R²⁶
Kweon SS²⁸
Shin MH²⁸
Poustchi H²⁹
Vardanjani HM³⁰
Ahsan H³¹
Chia KS³²
Matsuo K^{33, 34}
Qiao YL³⁵
Rothman N³⁶
Zheng W³⁷
Inoue M²
Kang D³⁸
Boffetta P^{39, 40}

Show Affiliations

1. Research Management Department, Vinmec Healthcare System, Hanoi, Viet Nam
2. Division of Prevention, National Cancer Center Institute for Cancer Control, Tokyo, Japan
3. Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
4. Hitotsubashi Institute for Advanced Study, Hitotsubashi University, Tokyo, Japan
5. Institute for Global Health Policy Research, National Center for Global Health and Medicine, Tokyo, Japan
6. Healisâ€”Sekhsaria Institute for Public Health, Navi Mumbai, India
7. Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan
8. Graduate School of Public Health, International University of Health and Welfare, Tokyo, Japan
9. Department of Public Health, Hokkaido University Faculty of Medicine, Sapporo, Japan
10. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, United States
11. Department of Epidemiology, Shanghai Cancer Institute Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
12. Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
13. Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, Singapore
14. Radiation Effects Research Foundation, Hiroshima, Japan
15. Tohoku University Graduate School of Medicine, Sendai, Japan
16. Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
17. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
18. Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-si, South Korea
19. Department of Population Health and Environmental Medicine, New York University, New York, NY, United States
20. Division of Cancer Information and Control, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan
21. Division of Descriptive Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
22. Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
23. Department of Health Informatics and Public Health, Division of Epidemiology, Tohoku University Graduate School of Public Health, Sendai, Japan
24. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea
25. Cancer Research Institute, Seoul National University, Seoul, South Korea
26. Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, United States
27. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States
28. Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea
29. Digestive Disease Research institute Tehran University of Medical Science, Tehran, Iran
30. MD-MPH Dual Degree Program, School of Medicine, Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Science, Shiraz, Iran
31. Department of Public Health Sciences, University of Chicago, Chicago, IL, United States
32. Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
33. Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
34. Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
35. School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
36. Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD, United States
37. Division of Epidemiology, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, United States
38. Seoul National University College of Medicine, Seoul, South Korea
39. Stony Brook Cancer Center, Stony Brook University, New York, NY, United States
40. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy

Source: International Journal of Cancer Published:2024

Abstract

There has been growing evidence suggesting that diabetes may be associated with increased liver cancer risk. However, studies conducted in Asian countries are limited. This project considered data of 968,738 adults pooled from 20 cohort studies of Asia Cohort Consortium to examine the association between baseline diabetes and liver cancer incidence and mortality. Cox proportional hazard model and competing risk approach was used for pooled data. Two-stage meta-analysis across studies was also done. There were 839,194 subjects with valid data regarding liver cancer incidence (5654 liver cancer cases [48.29/100,000 person-years]), follow-up time and baseline diabetes (44,781 with diabetes [5.3%]). There were 747,198 subjects with valid data regarding liver cancer mortality (5020 liver cancer deaths [44.03/100,000 person-years]), follow-up time and baseline diabetes (43,243 with diabetes [5.8%]). Hazard ratio (HR) (95% confidence interval [95%CI]) of liver cancer diagnosis in those with vs. without baseline diabetes was 1.97 (1.79, 2.16) (p <.0001) after adjusting for baseline age, gender, body mass index, tobacco smoking, alcohol use, and heterogeneity across studies (n = 586,072; events = 4620). Baseline diabetes was associated with increased cumulative incidence of death due to liver cancer (adjusted HR (95%CI) = 1.97 (1.79, 2.18); p <.0001) (n = 595,193; events = 4110). A two-stage meta-analytic approach showed similar results. This paper adds important population-based evidence to current literature regarding the increased incidence and mortality of liver cancer in adults with diabetes. The analysis of data pooled from 20 studies of different Asian countries and the meta-analysis across studies with large number of subjects makes the results robust. © 2024 UICC.

Related Docs

View other Related Docs

1. Expansion of the Quality of Care Index on Breast Cancer and Its Risk Factors Using the Global Burden of Disease Study 2019, Cancer Medicine (2023)

2. A Competing Risks Cure Frailty Model: An Application to Relapse-Free Survival of Breast Cancer Patients, Pakistan Journal of Statistics and Operation Research (2021)

3. An Office-Based Cardiovascular Prediction Model Developed and Validated in Cohort Studies of a Middle-Income Country, Journal of Clinical Epidemiology (2022)

4. Global, Regional, and National Burden and Quality of Care Index (Qci) of Bipolar Disorder: A Systematic Analysis of the Global Burden of Disease Study 1990 to 2019, International Journal of Social Psychiatry (2023)

5. How Do Donor-Recipient Cmv Serostatus and Post-Hematopoietic Stem Cell Transplantation Cmv Reactivation Affect Outcomes in Acute Leukemia Patients?, International Journal of Hematology-Oncology and Stem Cell Research (2017)

6. Methods of Competing Risks Flexible Parametric Modeling for Estimation of the Risk of the First Disease Among Hiv Infected Men, BMC Medical Research Methodology (2020)

7. Global, Regional, and National Survey on Burden and Quality of Care Index (Qci) of Nasopharyngeal Cancer: A Systematic Analysis of the Global Burden of Disease Study 1990–2019, Oral Oncology Reports (2024)

8. Long-Term Exposure to Particulate Matter and All-Cause and Cause-Specific Mortality in an Analysis of Multiple Asian Cohorts, Environment International (2024)

Experts (# of related papers)

View all Related Experts

Bagher Larijani (5)

Mehdi Yaseri (3)

Style	Citing Format
MLA	Ho NT, et al.. "Diabetes Is Associated With Increased Liver Cancer Incidence and Mortality in Adults: A Report From Asia Cohort Consortium." International Journal of Cancer, vol. , no. , 2024, pp. -.
APA	Ho NT, Abe SK, Rahman MS, Islam R, Saito E, Gupta PC, Pednekar MS, Sawada N, Tsugane S, Tamakoshi A, Kimura T, Shu XO, Gao YT, Koh WP, Cai H, Wen W, Sakata R, Tsuji I, Malekzadeh R, ... Boffetta P (2024). Diabetes Is Associated With Increased Liver Cancer Incidence and Mortality in Adults: A Report From Asia Cohort Consortium. International Journal of Cancer, (), -.
Chicago	Ho NT, Abe SK, Rahman MS, Islam R, Saito E, Gupta PC, Pednekar MS, et al.. "Diabetes Is Associated With Increased Liver Cancer Incidence and Mortality in Adults: A Report From Asia Cohort Consortium." International Journal of Cancer , no. (2024): -.
Harvard	Ho NT et al. (2024) 'Diabetes Is Associated With Increased Liver Cancer Incidence and Mortality in Adults: A Report From Asia Cohort Consortium', International Journal of Cancer, (), pp. -.
Vancouver	Ho NT, Abe SK, Rahman MS, Islam R, Saito E, Gupta PC, et al.. Diabetes Is Associated With Increased Liver Cancer Incidence and Mortality in Adults: A Report From Asia Cohort Consortium. International Journal of Cancer. 2024;():-.
BibTex	@article{ author = {Ho NT and Abe SK and Rahman MS and Islam R and Saito E and Gupta PC and Pednekar MS and Sawada N and Tsugane S and Tamakoshi A and Kimura T and Shu XO and Gao YT and Koh WP and Cai H and Wen W and Sakata R and Tsuji I and Malekzadeh R and Pourshams A and Kanemura S and Kim J and Chen Y and Ito H and Oze I and Nagata C and Wada K and Sugawara Y and Park SK and Shin A and Yuan JM and Wang R and Kweon SS and Shin MH and Poustchi H and Vardanjani HM and Ahsan H and Chia KS and Matsuo K and Qiao YL and Rothman N and Zheng W and Inoue M and Kang D and Boffetta P}, title = {Diabetes Is Associated With Increased Liver Cancer Incidence and Mortality in Adults: A Report From Asia Cohort Consortium}, journal = {International Journal of Cancer}, volume = {}, number = {}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Ho NT AU - Abe SK AU - Rahman MS AU - Islam R AU - Saito E AU - Gupta PC AU - Pednekar MS AU - Sawada N AU - Tsugane S AU - Tamakoshi A AU - Kimura T AU - Shu XO AU - Gao YT AU - Koh WP AU - Cai H AU - Wen W AU - Sakata R AU - Tsuji I AU - Malekzadeh R AU - Pourshams A AU - Kanemura S AU - Kim J AU - Chen Y AU - Ito H AU - Oze I AU - Nagata C AU - Wada K AU - Sugawara Y AU - Park SK AU - Shin A AU - Yuan JM AU - Wang R AU - Kweon SS AU - Shin MH AU - Poustchi H AU - Vardanjani HM AU - Ahsan H AU - Chia KS AU - Matsuo K AU - Qiao YL AU - Rothman N AU - Zheng W AU - Inoue M AU - Kang D AU - Boffetta P TI - Diabetes Is Associated With Increased Liver Cancer Incidence and Mortality in Adults: A Report From Asia Cohort Consortium JO - International Journal of Cancer VL - IS - SP - EP - PY - 2024 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract