Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Outcomes of Assisted Reproduction Treatment After Dopamine Agonist -Cabergoline- for Prevention of Ovarian Hyper Stimulation Syndrome



Movahedi S1 ; Safdarian L2 ; Agahoseini M1 ; Aleyasin A1 ; Khodaverdi S3 ; Asadollah S3 ; Valeshabad AK4 ; Fallahi P1 ; Rezaeeian Z1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Infertility of Shariati hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Infertility, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, United States

Source: Medical Journal of the Islamic Republic of Iran Published:2016

Abstract

Background: Release of vascular endothelial growth factor (VEGF) by ovaries in response to HCG administration is one of the main mechanisms of ovarian hyper stimulation syndrome. Since Dopamine/dopamine receptor2 (Dp-r2) pathway activity -mediated by VEGF/ Vascular endothelial growth factor receptor 2 (VEGFR- 2) signaling-, is associated with angiogenic events, dopamine agonists were used for the management of severe forms of OHSS. In order to assess the effects of Cabergoline on angiogenesis in the human endometrium, and subsequently its impacts on the implantation rate this study was conducted. Methods: This historical cohort study was conducted based on existing data of 115 patients (20-40 years) whom underwent assisted reproductive treatment (ART) and with a high probability for developing OHSS between March 2007 and September 2008. Forty five cases received Cabergoline were compared to 70 control subjects. The statistical methods used were: Unpaired t-test for continuous variables and the chi-square test (or Fisher's exact test if required) for categorical variables. Results: None of the patients (treatment or control group) developed OHSS. The etiologies of infertility and administration of GnRH agonist or antagonist protocols were similar in two groups (p > 0.2). Number of transferred embryos and zygote intra-fallopian transfer (ZIFT) did not differ between the two groups (p≥0.06). Implantation rate in treatment (3.1%) and control (6.6%) subjects was similar (p=0.4). No significant difference was observed in fertilization rate, chemical, clinical and ongoing pregnancies between the two groups (p > 0.5). Conclusion: Cabergoline can be safely administered in ART protocols to prevent OHSS, without compromising ART outcomes.