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An Experience of Donor Lymphocyte Infusion After Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease Publisher



Rostami T1 ; Kiumarsi A1
Authors
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Authors Affiliations
  1. 1. Hematology-Oncology and Stem Cell Transplantation Research Institute, Shariati Hospital, Tehran, 1411713131, Iran

Source: Pediatric Reports Published:2020


Abstract

Allogeneic hematopoietic stem-cell transplantation is a well-known curative treatment for patients with chronic granulomatous disease. We present our experiment regarding ten patients with chronic granulomatous disease who underwent a reduced intensity conditioning regimen consisting of melfalan, fludarabine, and antithymocyte globulin. Donor lymphocyte infusion was used in three representative patients who developed mixed donor chimerism. After at least 2 years of median follow-up, 8 of the 10 patients are alive and well. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).