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Nano-Selenium and the Src Family Kinases Pathway: Redefining Gene Expression Dynamics in Major Depressive Disorder Based on a Randomized Controlled Trial Publisher



M Noormohammadi MORVARID ; F Etesam FARNAZ ; A Amini ALI ; P Khosravian PEGAH ; M Mohamadzade MORTEZA ; F Shidfar FARZAD
Authors

Source: Current Journal of Neurology Published:2024


Abstract

Background: Major depressive disorder (MDD) is a prevalent psychiatric condition. Dysregulation of signaling pathways interacting with SRC family kinases has been implicated in the pathophysiology of MDD through inflammation. Nano-selenium, a nanoscale form of selenium with enhanced bioavailability, has the potential to modulate oxidative stress and inflammation, which are implicated in MDD. To the best of our knowledge, in this study, for the first time we aimed to examine whether nano-selenium supplementation would decrease c-SRC gene expression. Methods: This triple-blind, randomized, placebo-controlled clinical trial was conducted at Imam Khomeini Hospital Complex, Tehran, Iran. © 2025 Elsevier B.V., All rights reserved.