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Genetic Characterization of Rotavirus a Strains Circulating in Children Under 5 Years of Age With Acute Gastroenteritis in Tehran, Iran, in 2023–2024: Dissemination of the Emerging Equine-Like G3p[8]-I2-E2 Ds-1-Like Strains Publisher Pubmed



Hosseinifakhr SS1 ; Jalilvand S1 ; Maleki A2, 3 ; Kachooei A4 ; Behnezhad F4 ; Mirhosseinian M5 ; Taghvaei S6 ; Marashi SM1 ; Shoja Z5, 7
Authors
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Authors Affiliations
  1. 1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. COVID-19 National Reference Laboratory (CNRL), Pasteur Institute of Iran, Tehran, Iran
  3. 3. Department of Influenza and Respiratory Viruses, Pasteur Institute of Iran, Tehran, Iran
  4. 4. Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Virology, Pasteur Institute of Iran, Tehran, Iran
  6. 6. Pediatric Pathology Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Research Center for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran

Source: Journal of General Virology Published:2025


Abstract

The present study was conducted to monitor the genotype diversity of circulating species A rotavirus (RVA) in Iran. A total of 300 faecal specimens were collected from children under 5 years of age hospitalized for acute gastroenteritis between October 2023 and October 2024. G3P[8] represented 72.91% (70/96) of all RVA-positive samples, further subdivided into equine-like G3P[8]-I2-E2 DS-1-like and human G3P[8]-I1-E1 Wa-like. A retrospective genetic analysis of G3P[8] strains isolated from 2015 to 2017 was also performed and showed that G3P[8] strains belong to the G3P[8]-E1-I1 Wa-like genetic pattern, which is typically similar to human G3P[8] Wa-like strains in this study. The emergence of equine-like G3P[8] DS-1-like strains in Iran may not be related to selection pressure from rotavirus vaccination, but rather to cross-border migration of rotavirus strains due to population movements. © 2025 The Authors.
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