Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effect of Aerobic Exercises on Fatigue in Patients With Multiple Sclerosis: A Systematic Review Publisher



Jahantighakbari N1 ; Tahan N2 ; Sadatnaimi S3 ; Daryabor A4 ; Daneshshahreki B5 ; Rastgarkoutenaei F6 ; Azari A7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, Department of Physical Therapy, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Physical Therapy, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Physiotherapy Research Center, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Physiotherapy Research Center, Department of Orthotics and Prosthetics, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Head of Informatics Unit, Deputy of Education of Zabol, University of Medical Sciences, Zabol, Iran
  6. 6. Rehabilitation Research Center, Department of Physiotherapy, School of Rehabilitation Sciences, University of Medical Sciences, Tehran, Iran
  7. 7. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Physical Therapy Reviews Published:2025


Abstract

Purpose: Multiple sclerosis is an autoimmune disease that affects the central nervous system. This study examined the impact of aerobic exercises on fatigue among individuals with multiple sclerosis. Methods: This systematic review was conducted using electronic databases including PubMed, Cochrane, Scopus, and Science Direct. The inclusion criteria were: 1) a randomized clinical trial design, 2) patients diagnosed with multiple sclerosis, 3) aerobic exercises as the intervention, and 4) fatigue as a variable. Two independent reviewers assessed the quality of the articles using Physiotherapy Evidence Database (PEDro) scale. Results: On September 1, 2022, a total of 485 articles were found in the search. Out of the total, 73 articles were open access. However, only nine articles were selected after evaluating the titles and abstracts for this systematic review. The effect of aerobic exercises on fatigue in patients with multiple sclerosis, either alone or in combination with other exercises, was investigated in the chosen articles. The results demonstrated that aerobic exercises combined with other exercises, particularly strengthening exercises, seemed to be more effective in mitigating fatigue compared to aerobic exercise alone. Conclusions: Research has demonstrated that the combination of aerobic exercises with other forms of exercise is effective in reducing fatigue among individuals with multiple sclerosis. © 2025 Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
View other Related Docs
1. Exercise Prescription for Patients With Multiple Sclerosis; Potential Benefits and Practical Recommendations, BMC Neurology (2017)
2. Coenzyme Q10 As a Treatment for Fatigue and Depression in Multiple Sclerosis Patients: A Double Blind Randomized Clinical Trial, Nutritional Neuroscience (2016)
3. Effect of Endurance Training on Cardiopulmonary Fitness in People With Multiple Sclerosis, Multiple Sclerosis and Related Disorders (2022)
4. Randomized Controlled Trial to Examine the Impact of Aquatic Exercise Training on Functional Capacity, Balance, and Perceptions of Fatigue in Female Patients With Multiple Sclerosis, Archives of Physical Medicine and Rehabilitation (2018)
5. Psychometric Properties of the Persian Version of the Fatigue Impact Scale (Fis-P) in Patients With Multiple Sclerosis, Iranian Rehabilitation Journal (2015)
6. Effects of Two Types of Exercise Training on Psychological Well-Being, Sleep and Physical Fitness in Patients With High-Grade Glioma (Who Iii and Iv), Journal of Psychiatric Research (2022)
7. Effect of Vitamin a Supplementation on Fatigue and Depression in Multiple Sclerosis Patients: A Double-Blind Placebo-Controlled Clinical Trial, Iranian Journal of Allergy# Asthma and Immunology (2016)
8. Effects of Eight-Week Resistance Training Program in Men With Multiple Sclerosis, Asian Journal of Sports Medicine (2015)
Experts (# of related papers)
View all Related Experts
Mohammad Ali Sahraian (4)
Maryam Abolhasani (3)
Other Related Docs
9. Il-6 and Tnf-Α Responses to Acute and Regular Exercise in Adult Individuals With Multiple Sclerosis (Ms): A Systematic Review and Meta-Analysis, European Journal of Medical Research (2022)
10. Higher Disease and Pain Severity and Fatigue and Lower Balance Skills Are Associated With Higher Prevalence of Falling Among Individuals With the Inflammatory Disease of Neuromyelitis Optica Spectrum Disorder (Nmosd), Journal of Clinical Medicine (2020)