Protective Role of Cinnamon Extract on Oxidative Stress Induced by Gasoline Inhalation Exposure in Rat Kidneys



N Karimtaheri NARGES ; S Hassani SHOKOUFEH ; Sj Shahtaheri Seyed JAMALEDDIN ; M Khadem MONIRE
Source: Journal of Health and Safety at Work Published:2025

Abstract

Introduction: The rising daily consumption of gasoline has increased human exposure to its vapors. Direct contact with these vapors, due to their toxic properties, can adversely affect various organs, including the heart, lungs, skin, liver, and kidneys. Cinnamon, a widely utilized medicinal plant, is rich in antioxidants and exhibits protective effects on liver and kidney health, alongside therapeutic potential for various diseases. Therefore, this animal study aimed to investigate the protective effects of cinnamon extract against oxidative stress induced by gasoline inhalation in rat kidneys. Material and Methods: Thirty adult male Wistar rats weighing 160–180 grams were randomly divided into five groups (n=6 per group): (1) Control, (2) Cinnamon extract only, (3) Gasoline exposure only, (4) Gasoline exposure plus 100 mg/kg of cinnamon extract, and (5) Gasoline exposure plus 200 mg/kg of cinnamon extract. After four weeks of exposure, the rats were weighed and euthanized. Serum samples were collected for biochemical, serological, and enzymatic analysis, and kidney tissues were examined for histopathological changes. Results: Gasoline exposure significantly increased kidney function markers (BUN and cystatin C) and oxidative stress markers (MDA) while reducing endogenous antioxidant activities (GSH and GPx). Histopathological analysis revealed significant kidney damage, including hemorrhage, necrosis, and tubular degeneration in the gasoline-exposed group. Cinnamon extract notably alleviated gasoline-induced kidney toxicity by reducing kidney function markers and MDA levels while enhancing endogenous antioxidant activity. Histopathological findings further confirmed the protective effects of cinnamon extract, showing reduced tissue damage in treated groups. Conclusion: Cinnamon extract significantly reduces kidney toxicity caused by gasoline, suggesting it may protect against gasoline exposure. Its antioxidant and anti-inflammatory properties likely support this protective effect. © 2025 Elsevier B.V., All rights reserved.