Safety of Thrombolytic Therapy in Patients With Prosthetic Heart Valve Thrombosis Who Have High International Normalized Ratio Levels Publisher Pubmed



Farzaneh K¹ ; Mortazavi SH² ; Oraii A² ; Abbasi K³ ; Salehi Omran A³ ; Ahmadi Tafti SH³ ; Bozorgi A¹ ; Kazemi Saeed A¹ ; Salarifar M¹ ; Sadeghian S¹ Show Affiliations
Source: Journal of Cardiac Surgery Published:2020

Abstract

Background and Aim: Prosthetic valve thrombosis (PVT) is a rare but life-threatening complication of heart valve replacement. Based on the current guidelines, the treatment of a large number of these patients could be performed through the administration of thrombolytic agents. In the present study, we aim to assess the safety of thrombolytic therapy in patients with PVT who have high international normalized ratio (INR) levels. Methods: In this study, we retrospectively analyzed outcomes of thrombolytic therapy in 65 PVT patients with different levels of INR at the time of fibrinolysis at a tertiary cardiac center. Results: Mean age of patients was 51.6 ± 12.47 years. The tricuspid valve was the most common site of prosthetic valve thrombosis (64.6%). The Median (range) of INR was 2.1 (0.9-4.9). The majority of patients (50.8%) achieved a complete response following thrombolytic treatment. There were no cases of intracranial hemorrhage. Other major and minor bleedings occurred in 3 (4.6%) and 10 (15.4%) patients, respectively. No embolic stroke and systemic embolism were observed. We found no significant difference in the frequency of major (P-value =.809) and minor (P-value =.483) bleeding as well as response to thrombolytic therapy (P-value =.658) between patients with different levels of INR. Total administered dose of Streptokinase was also similar in PVT patients with or without major (P-value =.467) and minor (P-value =.221) bleeding complications. Conclusions: We concluded that there was no significant difference between PVT patients presenting with subtherapeutic and high INR levels who received thrombolytic treatments regarding both minor and major bleeding complications as well as response to thrombolysis. © 2020 Wiley Periodicals LLC