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Orthotopic Liver Transplantation for Etanercept-Induced Acute Hepatic Failure: A Case Report Publisher



Sadeghian D1 ; Azmoudehardalan F1 ; Dashtikhavidaki S2 ; Fakhar N3
Authors
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Authors Affiliations
  1. 1. Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Liver Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Pathology Published:2020


Abstract

Occurrence of hepatotoxicity following prescription of etanercept, a tumor necrosis factor-alpha (TNF-α) antagonist, is a relatively well-known issue. On the other hand, acute hepatic failure which could lead to liver transplantation is extremely rare to the best of our knowledge, and there is no previously published case in the literature. In this article, we presented a case of acute liver failure followed by liver transplantaion, in a 32-year old man with a previous history of ankylosing spondylitis after etanercept usage. On pathologic examination of the explanted liver of the patient, extensive confluent necrosis in all liver segments with prominent infiltration of a mixed population of inflammatory cells in portal tracts was noticed. In conclusion, close follow-up of patients who are receiving etanercept is crucial, since its liver complications could be severe enough to subject the patients for liver transplantation. © 2020, Iranian Society of Pathology. All rights reserved.