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The First Report of Relative Incidence of Inherited White Matter Disorders in an Asian Country Based on an Iranian Bioregistry System Publisher Pubmed



Ashrafi MR1 ; Rezaei Z1 ; Heidari M2 ; Nikbakht S1 ; Malamiri RA3 ; Mohammadi M1 ; Zamani GR1 ; Badv RS1 ; Rostami P4 ; Movahedinia M1 ; Qorbani M5 ; Amanat M1 ; Tavasoli AR1
Authors
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Authors Affiliations
  1. 1. Pediatric Neurology Division, Myelin Disorders Clinic, Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Pediatric Neurology Division, Alborz University of Medical Sciences, Karaj, Iran
  3. 3. Department of Pediatric Neurology, Golestan Medical, Educational, and Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  4. 4. Pediatric Endocrinology and Metabolic Division, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Non-Communicable Disease Research Center, Alborz University of Medical Sciences, Karaj, Iran

Source: Journal of Child Neurology Published:2018


Abstract

Childhood leukodystrophies are a fast-growing field of pediatric neurology practice. Epidemiologic studies on the incidence of these disorders in children show different results. This is the first report of childhood leukodystrophies incidence from Iran. The enrolled patients were recruited from the neurometabolic bioregistry system that was organized in 2010 in the Children’s Medical Center, Tehran, Iran. Herein is reported the incidence rate of leukodystrophies in those patients who were residents of 2 big popular provinces near Iran’s capital city Tehran, with an average child population of 2 988 800 children. Ninety cases of leukodystrophies from Tehran and Alborz provinces who were registered between 2010 and 2016 in the bioregistry system were enrolled in this study. The annual incidence of inherited white matter disorders was 3.01/100 000, the highest number compared with those found in other studies using similar methods throughout the world. One of the main cause of this higher incidence could be the higher number of consanguineous marriages in Iran. © 2018, © The Author(s) 2018.