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An Update on the Anti-Diabetic Functions of Genistein: A Soybean (Glycine Max (L.) Merr.) Isoflavone Publisher



Sharifinejad N1, 9 ; Hooshyar M2 ; Ramezankhah M3 ; Shamsehkohan A4 ; Saie R5 ; Sahebjam M4 ; Aleebrahimdehkordi E6 ; Orandi S7 ; Faraji A8 ; Deravi N2
Authors
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Authors Affiliations
  1. 1. Student Research Committee, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
  2. 2. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Student Research Committee, School of Medicine, Babol University of Medical Sciences, Babol, Iran
  4. 4. Student Research Committee, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Student Research Committee, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
  6. 6. Medical Plants Research, Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
  7. 7. Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Medicine, Islamic Azad University of Medical Sciences, Tehran, Iran
  9. 9. Alborz office of USERN, Universal Scientific Education and Research Network (USERN), Alborz University of Medical Sciences, Karaj, Iran

Source: Current Traditional Medicine Published:2024


Abstract

Type 2 diabetes mellitus (T2DM) is a developing worldwide issue. Traditionally, different plants have been used throughout history to lower blood glucose and improve the impact of diabetes. Also, today, many natural products have been introduced to lower blood glucose in T2DM patients. The beneficial effects of genistein, the most essential and abundant isoflavone of soybean (Glycine max (L.) Merr.), on blood glucose and other metabolic indicators, as well as diabetesrelated complications, have been widely investigated. In the current narrative review, through a thorough search from 2013-2020” in “PubMed, Scopus, “ResearchGate”, “Google Scholar”, and Web of Science databases, we have retrieved, reviewed, and summarized all clinical trials, as well as in vitro and in vivo studies on the anti-diabetic potential of genistein. © 2024 Bentham Science Publishers.
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